Pain Following Spinal Cord Injury

Wang, Michael Y.; OʼShaughnessy, Brian A.; Haq, Iftikharul; Green, Barth A.

doi:10.1055/s-2004-830018

Cited by 4 publications

(6 citation statements)

References 35 publications

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“…The criteria for selection was that the participant has spinal cord-related condition that involves pain, has an age of 18 years or more and experience some pain during the period of study. Finally, the range of pain intensity varied from 0-9, with the mean maximum pain intensity being 8.375 on a VAS, in accordance with the results cited in [1,2].…”

Section: Instrumentationsupporting

confidence: 88%

“…Roughly one-half to two-thirds of spinal cord injured persons suffer from some form of chronic pain, and in approximately one third the pain is very severe and disabling [1].…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, a summary of results from past studies [1,2] in patients with SCI indicates that the average reported estimate of the prevalence of chronic SCI pain is approximately 65%, with roughly one-third of those affected reporting the severity as being greater than seven in a scale of ten on a Visual Analogue Scale (VAS). Although loss of function is the main consequence of SCI, the symptoms experienced from the presence of such chronic pain could be so severe that it has been reported to frequently interfere with sleep and everyday activities [3].…”

Section: Introductionmentioning

confidence: 99%

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An interactive 3-D application for pain management: Results from a pilot study in spinal cord injury rehabilitation

Spyridonis

Gawronski

Ghinea

et al. 2012

Computer Methods and Programs in Biomedicine

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Research on pain following Spinal Cord Injury (SCI) has revealed that patients not only experience several types of pain that could prove to be challenging to address, but also that each individual can interpret such pain in different subjective ways. In this paper we introduce a 3-D system for facilitating the efficient management of pain, and thus, supporting clinicians in overcoming the aforementioned challenges. This system was evaluated by a cohort of 15 SCI patients in a pilot study that took place between July and October 2010. Participants reported their experiences of using the 3-D system in an adapted version of the System Usability Scale (SUS) questionnaire. Statistically significant results were obtained with regards to the usability and efficiency of the 3-D system, with the majority of the patients finding it particularly useful to report their pain. Our findings suggest that the 3-D system can be an efficient tool in the efforts to better manage the pain experience of SCI patients.

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Section: Instrumentationsupporting

confidence: 88%

“…Roughly one-half to two-thirds of spinal cord injured persons suffer from some form of chronic pain, and in approximately one third the pain is very severe and disabling [1].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An interactive 3-D application for pain management: Results from a pilot study in spinal cord injury rehabilitation

Spyridonis

Gawronski

Ghinea

et al. 2012

Computer Methods and Programs in Biomedicine

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“…Like thermal hyperalgesia, tactile allodynia has been an outcome measure often examined in models of SCI, particularly in above-, at-, below-level dermatomes following thoracic trauma. Spontaneous pain is particularly relevant to the clinical situation (Mogil, 2009; Wang et al, 2004) and needs to be assessed in SCI models, despite greater technical difficulty than evoked behavioral paradigms of pathological pain. In ongoing work, we are attempting to characterize spontaneous pain behaviors using, for example, a conditioned place preference approach that can unveil spontaneous neuropathic pain in rats (De Felice et al, 2011; King et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn

et al. 2014

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Neuropathic pain is a form of pathological nociception that occurs in a significant portion of traumatic spinal cord injury (SCI) patients, resulting in debilitating and often long-term physical and psychological burdens. While many peripheral and central mechanisms have been implicated in neuropathic pain, central sensitization of dorsal horn spinothalamic tract (STT) neurons is a major underlying substrate. Furthermore, dysregulation of extracellular glutamate homeostasis and chronic astrocyte activation play important underlying roles in persistent hyperexcitability of these superficial dorsal horn neurons. To date, central sensitization and astrocyte changes have not been characterized in cervical SCI-induced neuropathic pain models, despite the fact that a major portion of SCI patients suffer contusion trauma to cervical spinal cord. In this study, we have characterized two rat models of unilateral cervical contusion SCI that behaviorally result in chronic persistence of thermal hyperalgesia in the ipsilateral forepaw. In addition, we find that STT neurons are chronically activated in both models when compared to laminectomy-only uninjured rats. Finally, persistent astrocyte activation and significantly reduced expression of the major CNS glutamate transporter, GLT1, in superficial dorsal horn astrocytes are associated with both excitability changes in STT neurons and the neuropathic pain behavioral phenotype. In conclusion, we have characterized clinically-relevant rodent models of cervical contusion-induced neuropathic pain that result in chronic activation of both STT neurons and astrocytes, as well as compromise in astrocyte glutamate transporter expression. These models can be used as important tools to further study mechanisms underlying neuropathic pain post-SCI and to test potential therapeutic interventions.

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“…Reports from individuals who have suffered this kind of trauma reveal that the severity of such pain experience could be so immense that it often interferes with sleep and everyday activities [4]. In fact, a summary of results from several studies [see 16,19] indicates that the average reported estimate of the prevalence of chronic SCI pain is approximately 65%, with roughly one-third of those affected reporting the severity as greater than 7 in a scale of 10 on a Visual Analogue Scale (VAS). This revelation could justify the need of the nearly 40% of SCI patients to trade their pain with additional loss of mobility, bladder or bowel control, and sexual function [16].…”

Section: Introductionmentioning

confidence: 99%

2D vs. 3D Pain Visualization: User Preferences in a Spinal Cord Injury Cohort

Spyridonis

Ghinea

2011

Lecture Notes in Computer Science

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Abstract.Research on pain experienced after Spinal Cord Injury (SCI) has revealed that not only are there several types of pain present in the same individual with this kind of trauma, but also that people who suffer such an injury can describe the characteristics of the same type of pain in different ways. Making it possible, therefore, to more precisely describe pain experience could prove to be vital for an increased quality of life. Accordingly, fifteen individuals with pain after SCI were asked to describe their pain experience using a 3 Dimensional (3D) model of the human body that could be used as an aid in communicating their pain. The results of this study suggest that the consensus of the participants approved the ability of the 3D model to more accurately describe their pain, an encouraging outcome towards the use of 3D technology in support of post SCI pain rehabilitation.

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Pain Following Spinal Cord Injury

Cited by 4 publications

References 35 publications

An interactive 3-D application for pain management: Results from a pilot study in spinal cord injury rehabilitation

An interactive 3-D application for pain management: Results from a pilot study in spinal cord injury rehabilitation

Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn

2D vs. 3D Pain Visualization: User Preferences in a Spinal Cord Injury Cohort

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