Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults with Symptomatic Knee Osteoarthritis

Herbert, Matthew S.; Goodin, Burel R.; Pero, Samuel T.; Schmidt, J.; Sotolongo, Adriana; Bulls, Hailey W.; Glover, Toni L.; King, Christopher D.; Sibille, Kimberly T.; Cruz-Almeida, Yenisel; Staud, Roland; Fessler, Barri J.; Bradley, Laurence A.; Fillingim, Roger B.

doi:10.1007/s12160-013-9563-x

Cited by 53 publications

(33 citation statements)

References 41 publications

(46 reference statements)

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“…In addition, subjective health status significantly affected current arthritic pain in subjects with osteoarthritis. Previous studies have reported an association between osteoarthritis and psychosocial factors, such as depression and catastrophizing, 42 , 43 , 44 which supports our study results. Therefore, more attention needs to be paid to psychiatric causes and outcomes of osteoarthritis and arthritis related joint pain.…”

Section: Discussionsupporting

confidence: 92%

Risk Factors for Osteoarthritis and Contributing Factors to Current Arthritic Pain in South Korean Older Adults

et al. 2015

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PurposeAlthough previous studies have focused on risk factors for osteoarthritis, there is some debate on this issue. Furthermore, associated factors with arthritic symptom (arthralgia) have not been sufficiently investigated, despite its clinical importance in the management of osteoarthritis. This study was performed to examine the risk factors for osteoarthritis and the contributing factors to current arthritic pain in older adults.Materials and MethodsThe Fourth Korean National Health and Nutrition Examination Surveys was conducted in 2009. Therein, 720 males and 1008 females aged 65 years and older were included. Comprehensive data on habitual, socioeconomic, medical, nutritional, and psychological factors were collected along with the presence of osteoarthritis and arthritic pain. After univariate analysis, binary logistic regression analysis was performed to identify risk factors for osteoarthritis and contributing factors to current arthritic pain.ResultsAge (p=0.005), female gender (p<0.001), higher body mass index (BMI) (p<0.001), and osteoporosis (p<0.001) were significant risk factors for osteoarthritis, while higher education level (p=0.025) was a protective factor for osteoarthritis. Higher BMI (p=0.047), lack of weekly moderate intensity activity (p<0.001), and unfavorable subjective health status (p<0.001) were significant factors contributing to current arthritic pain among subjects with osteoarthritis. Both osteoarthritis and current arthritic pain adversely affected health related quality of life.ConclusionHigher BMI, lack of weekly moderate intensity activity, and unfavorable subjective health status were significant factors contributing to current arthritic pain. More attention needs to be paid to psychiatric effects on osteoarthritis and joint related pain.

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Section: Discussionsupporting

confidence: 92%

Risk Factors for Osteoarthritis and Contributing Factors to Current Arthritic Pain in South Korean Older Adults

et al. 2015

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“…The detection of thermal stimuli by primary afferents, the transmission of this information to the brain and the subsequent generation of the actual experience of temperature and pain in the individual involves interplay of central and peripheral sensory mechanisms that is not fully understood. It is, however, known that innocuous cold and heat sensation and cold and heat pain are mediated by different peripheral receptors and modulated by several mechanisms, including those driven by comorbidity in the CNS (26)(27)(28)(29)(30). It remains to be determined whether the characteristic QST profile observed in this cohort of patients reflects a common phenotype over-represented in patients with persistent pain or a common pathophysiological process that might be responsive to multimodal pain treatment.…”

Section: Discussionmentioning

confidence: 91%

Quantitative sensory testing of temperature thresholds: Possible biomarkers for persistent pain?

Malmström¹,

Stjerna²,

Högestätt³

et al. 2016

J Rehabil Med

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“…Cognitive changes accompanying chronic pain often involve disproportionate attentional selection of pain and pain-associated information at the expense of the remaining sensory inputs [ 114 – 116 ]. Hypervigilance to pain is associated both with higher sensitivity to experimental pain [ 117 – 118 ] and greater clinical pain in FMS and other conditions [ 117 , 119 ]. Further, there is an emerging view that increased vigilance in people with FMS may not be circumscribed to painful inputs but rather represent a generalized, perceptual style of amplification of a variety of sensory information [ 120 ], including innocuous or auditory inputs [ 121 ].…”

Section: Discussionmentioning

confidence: 99%

Embodied pain in fibromyalgia: Disturbed somatorepresentations and increased plasticity of the body schema

et al. 2018

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Fibromyalgia syndrome (FMS) is a highly prevalent, chronic musculoskeletal condition characterized by widespread pain and evoked pain at tender points. This study evaluated various aspects of body awareness in a sample of 14 women with FMS and 13 healthy controls, such as plasticity of the body schema, body esteem, and interoceptive awareness. To this end, the Rubber Hand Illusion (RHI), the Body Esteem Scale (BES), and the Body Perception Questionnaire (BPQ) were used, respectively. Consistent with increased plasticity of the body schema, FMS patients scored higher, with large or very large effect sizes, across all three domains evaluated in the RHI paradigm, namely proprioceptive drift and perceived ownership and motor control over the rubber hand. Scores on all items addressed by the BES were consistently lower among FMS subjects (2.52, SEM .19 vs 3.89, SEM .16, respectively, p < .01, Cohen’s d = .38-.66). In the FMS sample, BES scores assigned to most painful regions also were lower than those assigned to the remaining body sites (1.58, SEM .19 vs 2.87, SEM .18, respectively, p < .01). Significantly higher scores (p < .01, Cohen’s d = .51-.87) were found in the FMS sample across awareness (3.57 SEM .15 vs 1.87 SEM .11), stress response (3.76 SEM .11 vs 1.78 SEM .11), autonomic nervous system reactivity (2.59 SEM .17 vs 1.35 SEM .07), and stress style 2 (2.73 SEM .27 vs 1.13 SEM .04) subscales of the BPQ. Intensity of ongoing clinical pain was found to be strongly correlated with interoceptive awareness (r = .75, p = .002). The results suggest a disturbed embodiment in FMS, characterized by instability of the body schema, negatively biased cognitions regarding one’s own body, and increased vigilance to internal bodily cues. These manifestations may be interpreted as related with the inability of incoming sensory inputs to adequately update negatively biased off-line somatorepresentations stored as long-term memory.

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Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults with Symptomatic Knee Osteoarthritis

Cited by 53 publications

References 41 publications

Risk Factors for Osteoarthritis and Contributing Factors to Current Arthritic Pain in South Korean Older Adults

Risk Factors for Osteoarthritis and Contributing Factors to Current Arthritic Pain in South Korean Older Adults

Quantitative sensory testing of temperature thresholds: Possible biomarkers for persistent pain?

Embodied pain in fibromyalgia: Disturbed somatorepresentations and increased plasticity of the body schema

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