Pain in Parkinson’s disease: analysis of 50 cases in a clinic of movement disorders

Silva, Élton Gomes da; Viana, Maura Aparecida; Quagliato, Elizabeth Maria Aparecida Barasnevicius

doi:10.1590/s0004-282x2008000100007

Cited by 28 publications

(25 citation statements)

References 20 publications

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“…The two groups did not differ in terms of anxiety. Pain is an important aspect of PD10–12 and MSA13, 14 in which multiple mechanisms, including hypoperfusion, rheumatic, sensory, dystonic and off‐period related aspects have been postulated. In a previous study, MSA with predominant parkinsonism was associated with more pain than MSA with predominant cerebellar ataxia 2.…”

Section: Discussionmentioning

confidence: 99%

A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy

et al. 2010

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The objective of this study was to compare subjective health status and its correlates in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). One hundred eighty-eight patients with PSP and 286 patients with MSA completed EQ-5D and Hospital Depression and Anxiety Scale. The impact on mobility, usual activities, and self-care was similarly high in both groups after similar duration. Fifty-six percent of PSP and 43% of MSA had probable depression, and 37% of both groups had probable anxiety. Patients with PSP had significantly higher depression scores, but groups did not differ in anxiety scores. Patients with MSA had significantly greater pain/discomfort than patients with PSP. The most important association with subjective health status was with depressive symptoms, which accounted for 38% and 29% of EQ-5D variance in patients with PSP and MSA, followed by disease severity and anxiety scores. We conclude that depressive symptoms were common in both disorders, but more severe in PSP. Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP.

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Section: Discussionmentioning

confidence: 99%

A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy

et al. 2010

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“…Complaints of pain and sensory disturbances are common NMS in PD and can affect up to 65% of patients, 58,65,[121][122][123][124][125] and a few studies have reported that PD patients may have a lower pain threshold. 126 Importantly, the impact of their presence on quality of life can be greater than that of motor features, 127,128 with pain as the sensory NMF with the greatest negative impact.…”

Section: Autonomic Fluctuationsmentioning

confidence: 99%

The hidden sister of motor fluctuations in Parkinson's disease: A review on nonmotor fluctuations

et al. 2016

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Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their management, that had dampened the euphoria of the “levodopa miracle.” It soon became clear that neuropsychiatric, autonomic, and sensory features also tend to develop fluctuations after chronic exposure to l‐dopa. The diversity of fluctuating nonmotor symptoms, their largely subjective nature, coupled with a frequent lack of insight led to difficulties in identification and quantification. This may explain why, despite the high impact of nonmotor symptoms on patient autonomy and quality of life, evaluation of nonmotor fluctuations is not part of clinical routine. In view of the lack of specific validated assessment tools, detailed anamnesis should ideally be coupled with an evaluation in both ON and OFF drug conditions. The mechanisms of nonmotor fluctuations are not well understood. It is thought that they share dopaminergic presynaptic pharmacokinetic and postsynaptic pharmacodynamic mechanisms with the classical motor complications, but involve different neural pathways. Although symptoms fluctuate with dopaminergic treatment, serotonine and norepinephrine denervation, as well as interactions between neurotransmitter systems, probably contribute to their diversity. The lack of validated tools for assessment of these phenomena explains the almost complete absence of treatment studies. Management, largely resulting from expert opinion, includes psychiatric follow‐up, nondopaminergic drugs, and advanced dopaminergic treatment, including drug delivery pumps and DBS. This review aims to provide a starting point for the understanding, diagnosis, and management of nonmotor fluctuations. © 2016 International Parkinson and Movement Disorder Society

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“…Distortions of body image are thought to be common in some pain states 9 . Pain may be a complain in more than 50% of PD patients 10 . It has been suggested that if body image relates to pain, treating body image may reduce pain, and treating pain may normalize body image 9,10 .…”

mentioning

confidence: 99%

“…Pain may be a complain in more than 50% of PD patients 10 . It has been suggested that if body image relates to pain, treating body image may reduce pain, and treating pain may normalize body image 9,10 . A neurological dysfunction could unleash not only alterations in the body image because of the illness itself, but also because of the reaction of the individual who, to preserve their body image, ends up modifying their body image depending on the perceived experiences resulting from the dysfunction suffered.…”

mentioning

confidence: 99%

Evaluation of body image and self-concept and their correlation with depressive symptoms in Parkinson's disease

Gamarra¹,

Molski²,

Hilbig

et al. 2009

Arq. Neuro-Psiquiatr.

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Avaliação da imagem corporal, autoconceito e suas correlações com os sintomas depressivos na doença de ParkinsonResumo -Objetivo: Identificar características de imagem corporal e autoconceito em indivíduos com doença de Parkinson (DP) acima de cinqüenta anos de idade. os objetivos secundários são analisar se a imagem corporal e o autoconceito são influenciados pela gravidade da DP e, verificar se existe correlação entre depressão, autoconceito e imagem corporal na DP. Método: Participaram do estudo 48 indivíduos, sendo 26 com DP e 22 Controles. os instrumentos utilizados foram: Mini-Exame do Estado Mental, Teste A Minha Imagem Corporal, Escala Fatorial de Autoconceito, Inventário de Depressão de Beck, Unified Parkinson's Disease Rating Scale parte motora e Hoehn e Yahr Modificada. Resultados: Na DP a percepção da imagem corporal e do autoconceito, demonstraram valores reduzidos significativamente (p<0.001 e p=0.012) respectivamente, e a sintomatologia depressiva apresentou-se significativamente maior (p=0.002). Conclusão: Indivíduos com DP apresentam alteração da imagem corporal e do autoconceito, apresentaram também menos confiança pessoal e menor receptividade social correlacionados com sintomas depressivos.PAlAvRAS-CHAvE: doença de Parkinson, imagem corporal, autoconceito, depressão, fisioterapia.

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Pain in Parkinson’s disease: analysis of 50 cases in a clinic of movement disorders

Cited by 28 publications

References 20 publications

A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy

A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy

The hidden sister of motor fluctuations in Parkinson's disease: A review on nonmotor fluctuations

Evaluation of body image and self-concept and their correlation with depressive symptoms in Parkinson's disease

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