Pain in patients with fibromyalgia syndrome

Turk, Dennis C.; Okifuji, Akiko

doi:10.1007/s11926-000-0050-6

Cited by 11 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite efforts to objectively evaluate pain, it continues to remain a uniquely personal experience [25]. It is a challenging task for physicians serving patients with chronic pain to accurately assess the intensity, duration and nature of pain.…”

Section: Discussionmentioning

confidence: 99%

Comparison of pain threshold, health and functional status of females with fibromyalgia and multiple sclerosis: a pilot study

Özgöçmen¹,

Kaya²,

Gulkesen³

et al. 2006

International Journal of Psychiatry in Clinical Practice

View full text Add to dashboard Cite

Objectives. Fibromyalgia (FM) and multiple sclerosis (MS) are known to cause disability and have an impact on physical functioning, social functioning, and emotional well-being of affected individuals. The aim of this study was to compare pressure pain threshold, health and functional status in females with FM and MS who were ambulatory. Methods. Control point scores (CPS), total myalgic scores (TMS; using an algometer), tender point (TP) counts, and chronic widespread pain were assessed in females with FM and MS and in healthy age-matched female controls. The Fibromyalgia Impact Questionnaire (FIQ), and the Nottingham Health Profile were performed. The Kurtzke Expanded Disability Status Scale (EDSS) was used to estimate the disability status of persons with MS. Results. Fibromyalgia patients have significantly lower CPS and TMS than MS patients and controls. Multiple sclerosis patients had similar CPS but significantly lower TMS compared to controls. Tender point counts were significantly higher in FM than MS patients and controls. Patients with MS had a higher numbers of TPs with respect to controls. Chronic widespread pain was reported by only three patients with MS and these patients did not meet FM criteria for tender point counts. Fibromyalgia patients had significantly lower FIQ-first item scores than MS patients. FM patients had higher NHP section scores in pain, social isolation, emotional reaction, sleep and energy, but similar physical mobility compared to MS patients. In MS patients energy and physical mobility dimension of NHP and FIQ-first item scores correlated with EDSS (r=0.42, P=0.047, r=0.83, P=0.001, and r=0.62, P=0.001, respectively). Conclusion. This cross-sectional study warrants further research comparing FM and MS, which share a lot of clinical and psychosocial features or may coexist. Chronic pain and related fatigue, social and emotional reactions and disability seem to be important components in FM, so taking care of these components, in other words a biopsychosocial model, may improve disease outcome and quality of life not only in FM but also in MS.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of pain threshold, health and functional status of females with fibromyalgia and multiple sclerosis: a pilot study

Özgöçmen¹,

Kaya²,

Gulkesen³

et al. 2006

International Journal of Psychiatry in Clinical Practice

View full text Add to dashboard Cite

show abstract

“…However, studies do not offer evidence in favor of cognitive-behavioral therapy over group programs of education and exercise (82). It has been suggested that cognitive-behavioral therapy may be especially effective in patients who are characterized by a high level of pain, reduced quality of life, emotional distress, lack of control over their lives, and functional limitations (83,84).…”

Section: Cognitive-behavioral Interventionsmentioning

confidence: 99%

A Psychoneuroendocrine Perspective on the Management of Fibromyalgia Syndrome

Geenen

Jacobs

Bijlsma

2009

Journal of Musculoskeletal Pain

View full text Add to dashboard Cite

Objectives: Pain is a multifaceted phenomenon. Next to and in interaction with aberrations in central pain processes, behavioral factors and the neuroendocrine regulation system are also involved in pain. Our aim is to summarize neuroendocrine findings in fibromyalgia syndrome [FMS], to discuss how neuroendocrine functioning interacts with pain and psychological factors, and to confer implications of this inquiry for the management of FMS.Findings: With respect to hypothalamic-pituitary-adrenal axis functioning, on average, normal cortisol levels, reduced corticotrophin responses to multiple stressors, and an exaggerated corticotrophin response to exogenous corticotrophin-releasing hormone [CRH] are found. This may reflect a hypoactive status of CRH neurons and, as a consequence, upregulation of pituitary CRH receptors. Studies of autonomic nervous system functioning show a hyporesponsiveness to a variety of stressors and indicate a persistent hyperactive sympathetic nervous system. Although a causal role of constitutional or acquired neuroendocrine dysregulation in FMS is not refuted, the reviewed findings suggest that neuroendocrine dysregulation is a consequence of current pain, psychological stress and distress, sleep disturbance, inactivity, and low fitness.Conclusions: Essential aims in the tailored management of FMS are enhancement of functional capacity and quality of life, and symptomatic treatment of individual symptoms such as pain, distress, and sleep disturbances. Patient education, pharmacological interventions with analgesics and antidepressants, cognitive-behavioral therapy, sleep hygiene training, and low-intensity physical

show abstract

“…Despite efforts to objectively evaluate pain, it continues to remain a uniquely personal experience [4,5]. It is essential for physicians serving patients with chronic pain to accurately assess the intensity, duration and nature of pain in order to determine whether new treatment modalities are deemed to be effective or not [5].…”

Section: Assessment Of Painmentioning

confidence: 99%

“…The diverse symptoms, poorly understood etiology and pathophysiology make FM a frustrating condition for patients and physicians [1,2]. The complexity or heterogeneity of the condition requires individualised evaluation and multidisciplinary approach to the treatment [1,[3][4][5]. The complexity or heterogeneity of the condition requires individualised evaluation and multidisciplinary approach to the treatment [1,[3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Current therapeutic approaches target to provide palliation of specific symptoms, as pain, sleep, anxiety and depression or functional restoration [1,3]. The other challenging aspect of FM clinical trials is the inevitable necessity to rely on patients' self reporting of symptoms [4,6]. The use of multiple outcome variables reflecting the complex symptomatology of FM or co-morbid syndromes in clinical trials is a challenging issue in evaluating response to the treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Complementary and Alternative Medical Therapies in Fibromyalgia

Saraç¹,

Gür

2006

CPD

View full text Add to dashboard Cite

Fibromyalgia (FM) is continuing to be a challenging and confusing disorder for researchers and clinicians with its diverse symptoms, poorly understood etiology and pathophysiology. The use of multiple outcome variables reflecting the complexity of FM and co-morbid syndromes, makes it difficult to evaluate the efficacy or effectiveness of the treatment in clinical trials. Additionally researchers inevitably rely on patients' self-reported outcome data, which is prone to error and bias. In this paper, new researches in the field of FM and practical issues on methodology of pain assessment (visual analogue scales, paper or electronic diaries and compliance), core outcome domains in chronic pain assessment (IMMPACT recommendations), and advances in neuroimaging techniques like functional magnetic resonance imaging have been reviewed. Consequently, clinicians and researchers have various highly validated and adequate outcome domains to assess FM symptoms and new researches continue to add new valuable domains. Nevertheless the current problem is to conclude, which treatment works best for whom and which are the outcome domains suitable for FM patients or patients' subgroups with different prominent features. Standardised and appropriate core outcome domains for FM clinical trails will encourage more complete investigations, relevant outcome reporting and well-designed multicenter trials.

show abstract

Pain in patients with fibromyalgia syndrome

Cited by 11 publications

References 33 publications

Comparison of pain threshold, health and functional status of females with fibromyalgia and multiple sclerosis: a pilot study

Comparison of pain threshold, health and functional status of females with fibromyalgia and multiple sclerosis: a pilot study

A Psychoneuroendocrine Perspective on the Management of Fibromyalgia Syndrome

Complementary and Alternative Medical Therapies in Fibromyalgia

Contact Info

Product

Resources

About