Pain in Preterm Infants: Different Perspectives

Obeidat, Hala; Dwairej, Doa'a Abdullah; Aloweidi, Abdelkarim

doi:10.1891/j-pe-d-20-00032

Cited by 2 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute pain is defined as “an unpleasant somatic or visceral sensation caused by actual or potential tissue injury” [ 1 ]. Previously, it was believed that newborns did not have the capacity to experience pain because the myelination process of the nervous system was not complete yet.…”

Section: Introductionmentioning

confidence: 99%

Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis

García-Valdivieso

Yáñez-Araque

Moncunill-Martínez

et al. 2023

IJERPH

View full text Add to dashboard Cite

In neonatology, neonates have traditionally been considered incapable of feeling pain, due to the immaturity of their nervous system. Currently, there is sufficient information on the perception of pain in neonates; however, this treatment at this crucial stage for development requires a better approach. For this reason, the aim of this study was to analyse the efficacy of non-pharmacological analgesia interventions during heel prick, and to assess their effects on heart rate (HR), premature infant pain profile (PIPP) and O2 saturation. A systematic review and meta-analysis was performed following the guidelines of the preferred reporting items for systematic reviews and meta-analyses (PRISMA), and the Cochrane collaboration handbook. The databases PubMed, Cochrane Library, Web of Science, Scopus, CINAHL and Science Direct were searched until the end of January 2022. The DerSimonian and Laird methods were used to estimate the effect size with a 95% confidence interval (CI95%). Effect size estimates were 0.05 (95% CI: −0.19, 0.29) for HR, −0.02 (95% CI: −0.24, 0.21) for PIPP scale, and −0.12 (95% CI: −0.29, 0.05) for O2 saturation. The non-pharmacological interventions analysed (breastfeeding, kangaroo-mother care method, oral sucrose and non-nutritive sucking) were not statistically significant in reducing neonatal pain, but did influence the decrease in pain score and a faster stabilisation of vital signs.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis

García-Valdivieso

Yáñez-Araque

Moncunill-Martínez

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

The Comparative Efficacy and Safety of Sweet Solutions to Reduce Preterm Infants’ Pain Level: A Systematic Review and Network Meta-analysis

Efendi,

Kang,

Natalia

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The efficacy of sweet solutions in alleviating pain for preterm infants has been extensively investigated, yet the most efficacious sweet solutions remain unknown. Methods: We conducted a search in the CINAHL, MEDLINE, EMBASE, CENTRAL, Scopus, and ProQuest databases for studies. Randomized controlledtrials (RCTs) utilizing glucose, sucrose, or expressed breast milk for managing pain in preterm infants were included in this study. A random-effects frequentist network meta-analysis was conducted to evaluate outcomes in three pain measurement time points. The primary outcome was the pain level in the reactivity phase. The secondary outcomes were pain in the regulation and recovery phases, as well as heart rate, oxygen saturation, respiratory rate, crying time, and adverse events. P-scores and beading plot were utilized to rank the efficacy of the sweet solutions. Results: Of 10,043 references, 42 RCTs (2,733 newborns) were analyzed. Compared to the controls alone, glucose (standardized mean difference [SMD], -0.72; 95% confidence interval [CI], -1.19 to -0.25]) and sucrose (SMD, -0.56; 95% CI, -1.04 to -0.07]) were associated with lower pain responses in reaction phase. In the regulation and recovery phases, pain reduction was consistently linked to glucose, sucrose, and expressed breast milk. Those interventions were supported by results of P-scores that ranged from 0.877 to 0.917 showing glucose's superiority in the three phases. Glucose was associated with a higher risk of adverse events. Half of the 38 trials had a low risk of bias. Meanwhile, the certainty of the evidence was high to very low. Conclusions: Our findings indicate that glucose was ranked best for lowering pain in preterm infants, followed by sucrose and expressed breast milk. Future RCTs are expected to investigate the efficacy of sweet solutions, both alone and combined with other pain management methods, as well as the effects of repeated applications. Systematic review registration: PROSPERO CRD42023389288.

show abstract

Pain in Preterm Infants: Different Perspectives

Cited by 2 publications

References 55 publications

Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis

Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis

The Comparative Efficacy and Safety of Sweet Solutions to Reduce Preterm Infants’ Pain Level: A Systematic Review and Network Meta-analysis

Contact Info

Product

Resources

About