“…Table 1 outlines the techniques utilized for multi-modal pain management therapies for the orthopedic surgery patient which often include NSAIDS such as aspirin, naproxen, ketorolac, celecoxib, meloxicam, diclofenac, and ibuprofen (Donahue, Bradbury, Zychowicz, & Muckler, 2018; Brooks, Fretter, Bowles, & Amirault, 2017; Song, 2017; Canata, Casale, & Chiey, 2016; Chou, et al, 2016; ASA 2012). Analgesia resulting from NSAID administration is due to inhibited synthesis and release of prostaglandins and inhibited cyclooxygenase 2 (COX-2) that results in a suppressed inflammatory response (Elmallah, et al, 2018).…”