Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit

Filippa, Manuela; Poisbeau, Pierrick; Mairesse, Jérôme; Monaci, Maria Grazia; Baud, Olivier; Hüppi, Petra Susan; Grandjean, Didier; Kuhn, Pierre

doi:10.3389/fpsyg.2019.00715

Cited by 36 publications

(24 citation statements)

References 188 publications

(211 reference statements)

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“…In particular, weaker intrinsic functional connectivity of the thalamocortical pathways, and the insular cortex-limbic connections was associated with poorer locomotor outcome. This finding is corroborated by prior reports demonstrating that preterm neonates exposed to early postnatal painful events showed macro- and microstructural alterations in thalamocortical projections and other cortical regions (i.e., frontal and parietal cortex) that were associated with adverse motor and cognitive neurodevelopmental outcome in the first years of life, involving also the mechanisms of anxiety and emotion regulation (Duerden et al, 2015; Tortora et al, 2015; Navarra et al, 2016; Malavolti et al, 2017; Filippa et al, 2019). Moreover, Duerden et al (2018) demonstrated that early pain exposure can influence thalamocortical pathways maturation, especially in extremely preterm born neonates, and that the thalamic volume growth during the first weeks of life correlated with cognitive and motor scores at 36 months of age.…”

Section: Discussionsupporting

confidence: 88%

Early Pain Exposure Influences Functional Brain Connectivity in Very Preterm Neonates

et al. 2019

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Background Early exposure to nociceptive events may cause brain structural alterations in preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little is known on the extent to which early pain may affect brain connectivity. We aim to evaluate brain functional connectivity changes in preterm neonate that underwent multiple invasive procedures during the postnatal period, and to correlate them with the neurodevelopmental outcome at 24 months. Methods In this prospective case-control study, we collected information about exposure to painful events during the early postnatal period and resting-state BOLD-fMRI data at term equivalent age from two groups of preterm neonate: 33 subjected to painful procedures during the neonatal intensive care (mean gestational age 27.9 ± 1.8 weeks) and 13 who did not require invasive procedures (average gestational age 31.2 ± 2.1 weeks). A data-driven principal-component-based multivariate pattern analysis (MVPA) was used to investigate the effect of early pain exposure on brain functional connectivity, and the relationship between connectivity changes and neurodevelopmental outcome at 24 months, assessed with Griffiths, Developmental Scale-Revised: 0–2. Results Early pain was associated with decreased functional connectivity between thalami and bilateral somatosensory cortex, and between the right insular cortex and ipsilateral amygdala and hippocampal regions, with a more evident effect in preterm neonate undergoing more invasive procedures. Functional connectivity of the right thalamocortical pathway was related to neuromotor outcome at 24 months ( P = 0.003). Conclusion Early exposure to pain is associated with abnormal functional connectivity of developing networks involved in the modulation of noxious stimuli in preterm neonate, contributing to the neurodevelopmental consequence of preterm birth.

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Section: Discussionsupporting

confidence: 88%

Early Pain Exposure Influences Functional Brain Connectivity in Very Preterm Neonates

et al. 2019

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“…Previous research with recorded music stimulation with instrumental lullaby music, selected in consultation with an accredited music therapist, has shown similar effect to the current gold standard of oral sucrose [46], and the combination of music stimulation with sucrose provides better pain relief during blood sampling than when sucrose or music is used alone [46]. Recorded mother's voice has also shown similar pain alleviating effects as oral sweet solutions [47,48].…”

Section: Introductionmentioning

confidence: 95%

Study protocol: parents as pain management in Swedish neonatal care – SWEpap, a multi-center randomized controlled trial

et al. 2020

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Background During the first period of life, critically ill as well as healthy newborn infants experience recurrent painful procedures. Parents are a valuable but often overlooked resource in procedural pain management in newborns. Interventions to improve parents’ knowledge and involvement in infants’ pain management are essential to implement in the care of the newborn infant. Neonatal pain research has studied a range of non-pharmacological pain alleviating strategies during painful procedures, yet, regarding combined multisensorial parent-driven non-pharmacological pain management, research is still lacking. Methods/design A multi-center randomized controlled trial (RCT) with three parallel groups with the allocation ratio 1:1:1 is planned. The RCT “Parents as pain management in Swedish neonatal care – SWEpap”, will investigate the efficacy of combined pain management with skin-to-skin contact, breastfeeding and live parental lullaby singing compared with standard pain care initiated by health care professionals, during routine metabolic screening of newborn infants (PKU-test). Discussion Parental involvement in neonatal pain management enables a range of comforting parental interventions such as skin-to-skin contact, breastfeeding, rocking and soothing vocalizations. To date, few studies have been published examining the efficacy of combined multisensorial parent-driven interventions. So far, research shows that the use of combined parent-driven pain management such as skin-to-skin contact and breastfeeding, is more effective in reducing behavioral responses to pain in infants, than using the pain-relieving interventions alone. Combined parental soothing behaviors that provide rhythmic (holding/rocking/vocalizing) or orogustatory/orotactile (feeding/pacifying) stimulation that keep the parent close to the infant, are more effective in a painful context. In the SWEpap study we also include parental live lullaby singing, which is an unexplored but promising biopsychosocial, multimodal and multisensory pain alleviating adjuvant, especially in combination with skin-to-skin contact and breastfeeding. Trial registration ClinicalTrials.gov (NCT04341194) 10 April 2020.

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“…Lack of breast milk volume in the 1 st day after birth can be caused by a lack of stimulation of the hormones prolactin and oxytocin which are very instrumental in the process of producing and releasing milk. Under certain conditions, massage can be done to stimulate the oxytocin system, reduce pain and stress, and improve brain development [16].…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Oxytocin and Marmet Massage on Increased Prolactin Hormone for Smooth Breastfeeding in Postpartum Mothers in Langsa City Health Office, Indonesia

Emilda

Juliastuti

2020

Open Access Maced J Med Sci

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BACKGROUND: One of the causes of the disruption to the achievement of exclusive breastfeeding is the decrease in milk production experienced by nursing mothers. It is believed that the prolactin hormone and the mother’s perception of breast milk are inadequate. One effort to increase the prolactin hormone is by massaging techniques. This technique has been used by various people in the world for both medical treatment and health care. AIM: The purpose of this study was to analyze the differences in the effectiveness of Oxytocin and Marble Massage on Prolactin Hormone levels for smooth breast milk in postpartum women in the working areas of Langsa City Health Centre. METHODS: A quasi-experimental design method prospective cohort was used with no control group design. Giving oxytocin massage treatment and Mamet massage for prolactin hormone levels for smooth milk. The sample was selected of 32 postpartum mothers who were divided into two groups. The number of samples for each group was 16 postpartum mothers per group. Data analysis used the T-independent statistical test approach for bivariate analysis and multivariate analysis. RESULTS: The results showed that the highest prolactin hormone level in the Massage method was 1178.0 ƞg/ml and the highest prolactin hormone level was 357.9 ƞg/ml, the highest was 357.9 ƞg/ml. The mean prolactin hormone level in the oxytocin massage group was 195.694 ƞg/ml and in the Mamet group was 538.195 ƞg/ml. The average level of the prolactin hormone by the oxytocin massage method was 195.6 ƞg/ml with Std. deviation 106.8 ƞg/ml while the average method for Mamet massage is 538.9 ƞg/ml with Std. deviation 269.6 ƞg/ml. The results of the statistical test Independent T-test obtained Prolactin Hormone Levels for the Smooth ASI value of p = 0.000, then it can be concluded that there are significant differences between the oxytocin and Mamet massage methods. CONCLUSION: There is a significant difference between the oxytocin massage method and Mamet to increase levels of the hormone prolactin in postpartum mothers.

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Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit

Cited by 36 publications

References 188 publications

Early Pain Exposure Influences Functional Brain Connectivity in Very Preterm Neonates

Early Pain Exposure Influences Functional Brain Connectivity in Very Preterm Neonates

Study protocol: parents as pain management in Swedish neonatal care – SWEpap, a multi-center randomized controlled trial

The Effectiveness of Oxytocin and Marmet Massage on Increased Prolactin Hormone for Smooth Breastfeeding in Postpartum Mothers in Langsa City Health Office, Indonesia

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