Pain reduction by dehydrated human amnion/chorion membrane allograft in nondiabetic leg ulcers might be an early indicator of good response: A case series

Abstract

Dehydrated human amnion/chorion membrane allograft (dHACM) derived from placenta is increasingly used for skin and soft tissue repair in several medical specialties. Promising effects of dHACM were also reported in chronic venous and diabetic leg ulcers. However, dHACM is cost‐intensive and its effect on chronic leg ulcers of other etiologies and pain reduction is unknown. Clinical predictors of a favorable response to dHACM during the early treatment period could help to limit unnecessary costs. In our case series with six patients suffering from chronic lower leg ulcers of various etiology, the effect of dHACM once per week on reduction of pain and wound size during a 5‐week period was examined. dHACM resulted in effective pain reduction and improved wound healing in three patients with chronic leg ulcers due to calciphylaxis, chronic venous disease and reactive angioendotheliomatosis. Pain reduction after 1 to 2 applications of dHACM predicted a favorable healing response. Hence, our observation indicates that assessment of pain 3 weeks after initiation of dHACM may be a clinical predictor to justify dis‐/continuation of dHACM and thereby may help to limit costs.

Developing small-diameter vascular grafts with human amniotic membrane: long-term evaluation of transplantation outcomes in a small animal model

“…The human amniotic membrane (AM) is an abundant birth tissue located at the innermost layer of the placenta [21] and a gift of nature, composing a rich amount of structural proteins, growth factors, and cytokines [22][23][24][25]. In the biomedical field, AM has been extensively employed in such operations as ophthalmic, abdominal, dental, plastic surgeries, and wound healing, due to its special features, such as anti-bacterial, anti-inflammatory, anti-scarring, antifibrosis, and low immunogenic properties [26][27][28][29][30]. In our previous studies, we developed a flat patch with the multi-layered decellularized amniotic membrane (DAM) for repairing different types of wounds [31][32][33].…”

Comprehensive Comparison of Amnion Stromal Cells and Chorion Stromal Cells by RNA-Seq

“…These tissues have been shown to support restoration of several tissue types, including bone, tendon, and skin tissue [1][2][3]. The observed plethora of biological effects are due to the activation of epithelialization and neovascularization, suppression of inflammation and scarring, pain reduction, and inherent antimicrobial properties [4][5][6][7][8][9][10]. The mesenchymal stromal cells (MSCs), rich extracellular matrix, key cytokines, and growth factors in the tissues contribute to these functional properties.…”