2015
DOI: 10.1016/j.genhosppsych.2015.07.003
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Pain-related anxiety mediates the relationship between depressive symptoms and pain interference in veterans with hepatitis C

Abstract: Objective Depression and chronic pain are common in persons chronically infected with the hepatitis C virus (HCV), although little is known about the rate of co-occurrence or mechanisms by which they are associated. We evaluated whether pain-related anxiety mediates the relationship between depressive symptoms and pain-related physical functioning in patients with HCV. Methods Patients with HCV (n=175) completed self-report measures assessing demographic characteristics, pain-related function, and mental hea… Show more

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Cited by 11 publications
(8 citation statements)
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“…A secondary analysis with this dataset examined associations between depressive symptoms and pain interference. We found that clinically significant comorbid depressive symptoms and chronic pain affect 26% of patients with HCV, and pain-related anxiety may mediate the relationship between depressive symptoms and pain interference [30]. Based on these results, we determined the intervention should have a cognitive-behavior treatment orientation (i.e., to address pain catastrophizing and self-efficacy for managing pain) and decided to include two group treatment sessions focused on identifying maladaptive beliefs and cognitive restructuring (rather than one).…”
Section: Inmentioning
confidence: 80%
“…A secondary analysis with this dataset examined associations between depressive symptoms and pain interference. We found that clinically significant comorbid depressive symptoms and chronic pain affect 26% of patients with HCV, and pain-related anxiety may mediate the relationship between depressive symptoms and pain interference [30]. Based on these results, we determined the intervention should have a cognitive-behavior treatment orientation (i.e., to address pain catastrophizing and self-efficacy for managing pain) and decided to include two group treatment sessions focused on identifying maladaptive beliefs and cognitive restructuring (rather than one).…”
Section: Inmentioning
confidence: 80%
“…In addition, another previous study showed patients who suffer from both depression and comorbid medical illness had approximately twice impairments in social functioning compare to medical illness or depression alone (13). In addition, HCV patients with depression have poor prognosis, more mortality rate, more requirement to medical services , greater number of pain sites, higher pain intensity, longer duration of pain, lower levels of treatment response, more fatigue, more functional disability, and more decline in quality of life even after adjusting for other variables, including MELD score (23, 24). …”
Section: Discussionmentioning
confidence: 99%
“…It is well‐known that psychological distress (e.g. depression and anxiety), as well as social isolation and low socio‐economic status, is linked to increased pain and poor health . This has implications in clinical care, calling for a more encompassing and comprehensive strategy to optimise pain management among PWID and HCV.…”
Section: Discussionmentioning
confidence: 99%
“…Chronic pain and other pain‐related disorders affect over 60% of those living with HCV and are associated with decreased quality of life, increased health‐care utilisation and increased risk of co‐morbidities . Although the mechanisms and pathways are not clearly known, inflammatory cytokines in HCV are theorised to play a role .…”
Section: Introductionmentioning
confidence: 99%
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