Pain-Related Fear and Catastrophizing Predict Pain Intensity and Disability Independently Using an Induced Muscle Injury Model

Parr, Jeffrey J.; Borsa, Paul A.; Fillingim, Roger B.; Tillman, Mark D.; Manini, Todd M.; Gregory, Chris; George, Steven Z.

doi:10.1016/j.jpain.2011.12.011

Cited by 92 publications

(92 citation statements)

References 42 publications

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“…Anxiety, manifested by increased emotional and physiological arousal, is known to be related to chronic pain 50 and to pain hyperresponsiveness among chronic pain patients 33 and healthy subjects 48 . Pain-related expressions of anxiety, namely pain catastrophizing and anxiety sensitivity, which are also prevalent in PTSD 37,61 were also shown to be related to pain hyperresponsiveness among chronic pain patients and healthy individuals 47,58 . However, the relationship between anxiety and pain perception in PSTD has not been systematically studied.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 94%

Paradoxical Pain Perception in Posttraumatic Stress Disorder: The Unique Role of Anxiety and Dissociation

Defrin

Schreiber

Ginzburg

2015

The Journal of Pain

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 94%

Paradoxical Pain Perception in Posttraumatic Stress Disorder: The Unique Role of Anxiety and Dissociation

Defrin

Schreiber

Ginzburg

2015

The Journal of Pain

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“…Not all studies have shown independent contributions of pain catastrophizing and fear of pain to adverse pain outcomes, and the magnitude of relations between pain catastrophizing, fear of pain and pain outcomes has varied as well 3,23, 24, 34,50 Psychology of multisite pain 21 Note: N = 119. PCS = Pain Catastrophizing Scale; FOP-III-SF = Fear of Pain Questionnaire -III -Short Form; PHQ-9 = Patient Health Questionnaire -9; For correlations with Pain Intensity S2, Pain Intensity S1 was controlled; for correlations with Multisite Pain S2, Multisite Pain S1 was controlled.…”

Section: Psychology Of Multisite Pain 17mentioning

confidence: 99%

An Experimental Approach to Examining Psychological Contributions to Multisite Musculoskeletal Pain

Niederstrasser

Slepian²,

Mankovsky-Arnold

et al. 2014

The Journal of Pain

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The present study examined the prospective value of pain catastrophizing, fear of pain, and depression in the prediction of multisite musculoskeletal pain following experimentally induced delayed onset muscle soreness (DOMS). The study sample consisted of 119 (63 females, 56 males) healthy university students. Measures of pain catastrophizing, fear of pain and depression were completed prior to the DOMS induction procedure. Analyses revealed that pain catastrophizing, and fear of pain prospectively predicted the experience of multisite pain following DOMSinduction. Analyses also revealed that women were more likely to experience multisite pain than men. There was no significant relation between depressive symptoms and the experience of multisite pain. The discussion addresses the mechanisms by which pain catastrophizing and fear of pain might contribute to the spreading of pain. Clinical implications of the findings are also addressed.Key words: multisite pain, fibromyalgia, catastrophizing, fear of pain, depression, sex differences.Highlight points: Pain catastrophizing, and fear of pain prospectively predict the experience of multisite pain following DOMS-induction.Women are more likely to experience multisite pain than men.Depressive symptoms have no influence on the experience of multisite pain.Fear of pain may underlie the experience of multisite pain through generalization. Psychology of multisite pain 3Recent research indicates that musculoskeletal pain frequently occurs at more than one anatomical site 6, 9, 47 . A survey of patients attending general practice clinics revealed that three quarters of chronic pain patients reported pain in more than one site 6 . Multisite pain has been associated with poorer prognosis as indicated by heightened susceptibility to chronicity, increased health and mental health problems and greater disability 11, 32, 33, 38 . In light of the high prevalence and increased costs associated with multisite pain, clinical researchers have called for more research on risk factors and determinants of multisite pain 33, 38 .Psychological factors such as pain catastrophizing, fear of pain and depression have been discussed as possible risk factors the development of multisite pain 4, 9 .Although it has been suggested that psychological variables might play a role in the onset or maintenance of multisite pain, the correlational nature of clinical studies precludes strong statements about causality. On the basis of research conducted to date, it cannot be ruled out that psychological variables such as pain catastrophizing, fear of pain and depression might be consequences rather than antecedents of multisite pain.The present study used an experimental approach to address the possible antecedent status of psychological variables in the experience of multisite pain. One advantage of using an experimental approach is that putative psychosocial risk factors can be assessed prior to pain induction, thereby permitting examination of the antecedent status of the variables. In addi...

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“…For instance, those who have experienced acute and/or chronic orofacial pain are more likely than those who have not to later report fear of pain (van Wijk and Hoogstraten 2005). Furthermore, those with higher levels of fear of pain are more likely to perceive pain stimuli as more intense (van Wijk and Hoogstraten 2009), to engage in pain catastrophizing (Parr et al 2012) and avoidance behaviors that worsen chronic pain (Lee et al 2007). The results showing that fear of pain is the mediating variable in the association between MC1R variant status and dental fear suggest that genetically influenced differences in pain experience (e.g., pain threshold, tolerance) may, in some cases, be foundational for the development of fear of pain, which may then underpin dental fear (see comment in Appendix).…”

Section: Figurementioning

confidence: 99%

Fear of Pain Mediates the Association between MC1R Genotype and Dental Fear

et al. 2016

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Fear of pain is experienced in acute and chronic pain populations, as well as in the general population, and it affects numerous aspects of the orofacial pain experience, including pain intensity, pain-related disability, and pain behavior (e.g., avoidance). A related but separate construct—dental fear—is also experienced in the general population, and it influences dental treatment–seeking behavior and oral and systemic health. Minimal work has addressed the role of genetics in the etiologies of fear of pain and dental fear. Limited available data suggest that variants of the melanocortin 1 receptor ( MC1R) gene may predict greater levels of dental fear. The MC1R gene also may be etiologically important for fear of pain. This study aimed to replicate the finding that MC1R variant status predicts dental fear and to determine, for the first time, whether MC1R variant status predicts fear of pain. Participants were 817 Caucasian participants (62.5% female; mean ± SD age: 34.7 ± 8.7 y) taking part in a cross-sectional project that identified determinants of oral diseases at the community, family, and individual levels. Participants were genotyped for single-nucleotide polymorphisms on MC1R and completed self-report measures of fear of pain and dental fear. Presence of MC1R variant alleles predicted higher levels of dental fear and fear of pain. Importantly, fear of pain mediated the relation between MC1R variant status and dental fear ( B = 1.60, 95% confidence interval: 0.281 to 3.056). MC1R variants may influence orofacial pain perception and, in turn, predispose individuals to develop fears about pain. Such fears influence the pain experience and associated pain behaviors, as well as fears about dental treatment. This study provides support for genetic contributions to the development/maintenance of fear of pain and dental fear, and it offers directions for future research to identify potential targets for intervention in the treatment of fear of pain and dental fear.

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Pain-Related Fear and Catastrophizing Predict Pain Intensity and Disability Independently Using an Induced Muscle Injury Model

Cited by 92 publications

References 42 publications

Paradoxical Pain Perception in Posttraumatic Stress Disorder: The Unique Role of Anxiety and Dissociation

Paradoxical Pain Perception in Posttraumatic Stress Disorder: The Unique Role of Anxiety and Dissociation

An Experimental Approach to Examining Psychological Contributions to Multisite Musculoskeletal Pain

Fear of Pain Mediates the Association between MC1R Genotype and Dental Fear

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