Pain-relieving agents for infant colic

Savino, Francesco; Tarasco, Valentina; Lingua, Carla; Moja, Lorenzo; Ricceri, Fulvio

doi:10.1002/14651858.cd009999

Cited by 11 publications

(17 citation statements)

References 60 publications

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“…Paediatricians should first exclude other underlying diseases through medical examination and should prevent feeding disorders. Then, in light of the favourable clinical course of the condition, healthcare providers should assist parents in adopting safe and well-tolerated strategies (Savino 2010).…”

Section: Description Of the Conditionmentioning

confidence: 99%

Pain-relieving agents for infantile colic

Biagioli

Tarasco

Lingua

et al. 2016

Cochrane Database of Systematic Reviews

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Background Infantile colic is a common disorder in the first months of life, affecting somewhere between 4% and 28% of infants worldwide, depending on geography and definitions used. Although it is self limiting and resolves by four months of age, colic is perceived by parents as a problem that requires action. Pain-relieving agents, such as drugs, sugars and herbal remedies, have been suggested as interventions to reduce crying episodes and severity of symptoms. Objectives To assess the effectiveness and safety of pain-relieving agents for reducing colic in infants younger than four months of age. Search methods We searched the following databases in March 2015 and again in May 2016: CENTRAL, Ovid MEDLINE, Embase and PsycINFO, along with 11 other databases. We also searched two trial registers, four thesis repositories and the reference lists of relevant studies to identify unpublished and ongoing studies. Selection criteria We included randomised controlled trials (RCTs) and quasi-RCTs evaluating the effects of pain-relieving agents given to infants with colic. Data collection and analysis We used the standard methodological procedures of The Cochrane Collaboration. Main results We included 18 RCTs involving 1014 infants. All studies were small and at high risk of bias, often presenting major shortcomings across multiple design factors (e.g. selection, performance, attrition, lack of washout period). Three studies compared simethicone with placebo, and one with Mentha piperita; four studies compared herbal agents with placebo; two compared sucrose or glucose with placebo; five compared dicyclomine with placebo; and two compared cimetropium-one against placebo and the other at two different dosages. One multiple-arm study compared sucrose and herbal tea versus no treatment.

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Section: Description Of the Conditionmentioning

confidence: 99%

Pain-relieving agents for infantile colic

Biagioli

Tarasco

Lingua

et al. 2016

Cochrane Database of Systematic Reviews

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“…These three pathophysiological models indicate implicit treatment modalities, however, various therapeutic interventions have been used for infant colic that take a symptom-reduction, focused approach. These include pain relief Savino 2012 …”

Section: B a C K G R O U N D Description Of The Conditionmentioning

confidence: 99%

Parent training programmes for managing infantile colic

Thomas

Gordon

Banks

et al. 2016

Cochrane Database of Systematic Reviews

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“…Up to 40 % of infants suffer from colic – a condition characterised by repeated, prolonged episodes of inconsolable crying ( 61 ) . Possibly, children with colic symptoms have an imbalance in the intestinal microbiota: analyses of faecal samples found higher counts of coliform bacteria and lower counts of lactobacilli in infants with colic symptoms compared with children not suffering from colic ( 62 ) . On the other hand, probiotics have been shown to influence intestinal motility and sensory neurons as well as contractile activity of the intestine and to exert anti-inflammatory effects ( 63 , 64 ) .…”

Section: Supplementation With Probioticsmentioning

confidence: 99%

Probiotics in human milk and probiotic supplementation in infant nutrition: a workshop report

Bergmann¹,

Rodríguez

Salminen

et al. 2014

Br J Nutr

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Probiotics in human milk are a very recent field of research, as the existence of the human milk microbiome was discovered only about a decade ago. Current research is focusing on bacterial diversity and the influence of the maternal environment as well as the mode of delivery on human milk microbiota, the pathways of bacterial transfer to milk ducts, possible benefits of specific bacterial strains for the treatment of mastitis in mothers, and disease prevention in children. Recent advances in the assessment of early host -microbe interactions suggest that early colonisation may have an impact on later health. This review article summarises a scientific workshop on probiotics in human milk and their implications for infant health as well as future perspectives for infant feeding.

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Pain-relieving agents for infant colic

Cited by 11 publications

References 60 publications

Pain-relieving agents for infantile colic

Pain-relieving agents for infantile colic

Parent training programmes for managing infantile colic

Probiotics in human milk and probiotic supplementation in infant nutrition: a workshop report

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