Pain, sensory disturbances and psychological distress are common sequelae after treatment of ductal carcinoma <i>in situ</i>: a cross-sectional study

Mertz, Birgitte Goldschmidt; Duriaud, Helle Molter; Kroman, Niels; Andersen, Kenneth Geving

doi:10.1080/0284186x.2017.1295167

Cited by 22 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Female breast cancer survivors were defined as women with a history of breast cancer or in situ tumor for one year or longer. Studies with patients diagnosed with breast carcinomas in situ were included because despite of their excellent prognosis ( 20 ), they receive similar treatment to invasive breast cancers ( 21 ), and patients often experience substantial psychological distress both during and after the treatment period ( 22 , 23 ). Studies with no control group but reporting standardized incidence ratios were also eligible if the standardization was against a general female population.…”

Section: Methodsmentioning

confidence: 99%

Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review

Carreira

Williams

Mûller

et al. 2018

JNCI: Journal of the National Cancer Institute

284

179

View full text Add to dashboard Cite

BackgroundWe aimed to systematically review the evidence on adverse mental health outcomes in breast cancer survivors (≥1 year) compared with women with no history of cancer.MethodsStudies were identified by searching MEDLINE, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature, and the Social Sciences Citation Index, and through backward citation tracking. Two researchers selected the studies, extracted data, and assessed the risk of bias.ResultsSixty studies were included. Of 38 studies of depression, 33 observed more depression in breast cancer survivors; this was statistically significant in 19 studies overall, including six of seven where depression was ascertained clinically, three of four studies of antidepressants, and 13 of 31 that quantified depressive symptoms. Of 21 studies of anxiety, 17 observed more anxiety in breast cancer survivors, statistically significant in 11 studies overall, including two of four with clinical/prescription-based outcomes, and in eight of 17 of anxiety symptoms. Breast cancer survivors also had statistically significantly increased symptoms/frequency of neurocognitive dysfunction (18 of 24 studies), sexual dysfunctions (5 of 6 studies), sleep disturbance (5 of 5 studies), stress-related disorders/PTSD (2 of 3 studies), suicide (2 of 2 studies), somatisation (2 of 2 studies), and bipolar and obsessive-compulsive disorders (1 of 1 study each). Studies were heterogeneous in terms of participants’ characteristics, time since diagnosis, ascertainment of outcomes, and measures reported. Approximately one-half of the studies were at high risk of selection bias and confounding by socio-economic status.ConclusionsThere is compelling evidence of an increased risk of anxiety, depression and suicide, and neurocognitive and sexual dysfunctions in breast cancer survivors compared with women with no prior cancer. This information can be used to support evidence-based prevention and management strategies. Further population-based and longitudinal research would help to better characterize these associations.

show abstract

Section: Methodsmentioning

confidence: 99%

Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review

Carreira

Williams

Mûller

et al. 2018

JNCI: Journal of the National Cancer Institute

284

179

View full text Add to dashboard Cite

show abstract

“…Nearly 30% of breast cancer survivors experience chronic pain five years after treatment. Pain and depression are common symptoms in many serious diseases and carry a risk of self-perceived poor health, poor quality of life, premature mortality 4 , anxiety and depression 5 . Patient's age is also an important variable, with younger women generally feeling worse, for several reasons 6 .…”

Section: Introductionmentioning

confidence: 99%

Anxiety and depression in women with breast cancer: Social and clinical determinants and influence of the social network and social support (DAMA cohort)

Puigpinós‐Riera

Graells-Sans

Serral

et al. 2018

Cancer Epidemiology

View full text Add to dashboard Cite

show abstract

“…In the same study, the need for rehabilitation services was assessed. Unmet rehabilitation needs were reported by 29% of the patients [32]. These results indicate that there is a strong need for appropriate support and rehabilitation services even years after treatment for DCIS in this patient group.…”

Section: Discussionmentioning

confidence: 59%

“…These results indicate that there is a strong need for appropriate support and rehabilitation services even years after treatment for DCIS in this patient group. Mertz et al did not compare DCIS patients to patients diagnosed with invasive breast cancer [32].…”

Section: Discussionmentioning

confidence: 99%

Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients

Gregorowitsch

Bongard

Young‐Afat

et al. 2017

Breast Cancer Res Treat

View full text Add to dashboard Cite

Purpose Ductal carcinoma in situ (DCIS) is associated with an excellent prognosis; historical studies have shown similar levels of psychological distress in patients with DCIS and with early-stage invasive breast cancer (early-IBC). It is suggested that these results might have led to better patient education about prognosis after DCIS. This study reports the current levels of anxiety, depression, and health-related quality of life (HRQoL) in DCIS and early-IBC patients. Methods DCIS (n = 89) and early-IBC patients, T1-2N0, (n = 361) were selected from the UMBRELLA breast cancer cohort. Patient-reported outcomes were prospectively collected before the start of adjuvant radiotherapy (baseline) and at 3, 6, 12, 18, and 24 months thereafter. Mixed models were used to compare differences in levels of anxiety, depression, and HRQoL between DCIS and early-IBC patients.Results DCIS and early-IBC patients reported similar levels of anxiety, which were highest at baseline. Depression scores were comparable between groups, also after stratification by use of adjuvant chemotherapy. The proportion of patients reporting high-risk depression scores (i.e., Hospital Anxiety and Depression Sale score [8) was significantly higher among patients with DCIS at 6, 12 and 18 months, and this proportion increased over the first 18 months. Health-related quality of life was comparable between both groups. Conclusion Severe depression scores are more common in DCIS patients, despite their excellent prognosis. These results suggest that further improvement of patient education and effective patient doctor communication about the prognostic differences between patients with DCIS and invasive breast cancer is still highly needed.

show abstract

Pain, sensory disturbances and psychological distress are common sequelae after treatment of ductal carcinoma in situ: a cross-sectional study

Abstract: This cross-sectional study showed that women treated for DCIS suffered from pain, sensory disturbances and psychological impairment and had unmet rehabilitation needs. Further research is warranted, specifically addressing rehabilitation after diagnosis and treatment of DCIS.

Cited by 22 publications

References 27 publications

Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review

Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review

Anxiety and depression in women with breast cancer: Social and clinical determinants and influence of the social network and social support (DAMA cohort)

Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients

Contact Info

Product

Resources

About