Pain Thresholds in Alcohol Preferring and Non‐preferring Rats: Diurnal and Repeated Trial Line Differences

Kimpel, Mark W.; Brown, Matthew M.; Froehlich, Janice C.

doi:10.1097/01.alc.0000102720.08798.51

Cited by 7 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alcohol abuse may either lead to increased pain sensitivity or share a common underlying cause such as a genetic vulnerability. For example, alcohol‐preferring rats have decreased tolerance of pain as compared with non‐alcohol‐preferring rats [40], and both alcohol dependence and increased pain sensitivity have been linked to polymorphisms of the catechol‐O‐methyltransferase gene [39,41].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Pain Severity 3 Months after Serious Injury

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of Pain Severity 3 Months after Serious Injury

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In one study, alcohol administration enhanced tolerance for a painful electric shock only in FHN subjects (Perrino et al, 2008) whereas a more comprehensive study (Ralevski et al, 2010) found that FHP subjects scoring high for neuroticism displayed greater alcohol analgesia than FHN subjects and FHP subjects with low neuroticism scores. Studies in rodents selectively bred for differences in alcohol preference also provide partial evidence alcohol preference and pain response covary (Chester et al, 2002; Kampov-Polevoy et al, 1996; but see Kimpel et al, 2003). Given the possibility of a genetic link between pain processing and alcohol dependence, we suggest possible candidates having the potential to influence neurotransmitter systems involved in alcohol dependence and pain.…”

Section: Genetic Influences On Pain Alcohol Analgesia and Alcoholmentioning

confidence: 99%

Alcohol dependence as a chronic pain disorder

Egli¹,

Koob²,

Edwards³

2012

Neuroscience & Biobehavioral Reviews

297

275

View full text Add to dashboard Cite

Dysregulation of pain neurocircuitry and neurochemistry has been increasingly recognized as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia, depression, and PTSD. Evidence presented here supports the hypothesis that alcohol dependence is among the pathologies arising from aberrant neurobiological substrates of pain. In this review, we explore the possible influence of alcohol analgesia and hyperalgesia in promoting alcohol misuse and dependence. We examine evidence that neuroanatomical sites involved in the negative emotional states of alcohol dependence also play an important role in pain transmission and may be functionally altered under chronic pain conditions. We also consider possible genetic links between pain transmission and alcohol dependence. We propose an allostatic load model in which episodes of alcohol intoxication and withdrawal, traumatic stressors, and injury are each capable of dysregulating an overlapping set of neural substrates to engender sensory and affective pain states that are integral to alcohol dependence and comorbid conditions such as anxiety, depression, and chronic pain.

show abstract

“…There are a number of neurochemical characteristics within these systems that are associated with, and may be causally related to, differences in alcohol intake (Badia-Elder et al, 1999;Froehlich et al, 1998;Froehlich and Li, 1989, 1994Wand, 1996, 1997;Gong et al, 1997;Kimpel et al, 2003Kimpel et al, , 2007.…”

Section: Utility Of Rat Lines Selectively Bred For Differences In Alcmentioning

confidence: 99%

What Aspects of Human Alcohol Use Disorders Can Be Modeled Using Selectively Bred Rat Lines?

Froehlich

2010

Substance Use & Misuse

View full text Add to dashboard Cite

The use of selective breeding to produce animal models for the study of alcohol abuse and alcoholism represents one of the major advances in the field of alcohol research. Rats selectively bred for alcohol preference and alcohol nonpreference have been useful to both preclinical and clinical investigators in the alcohol research community for studying the behavioral, neurobiological, and molecular basis of alcohol drinking, for identifying the genes that may contribute to the development of alcohol abuse and alcoholism, and for evaluating the utility of drugs aimed at reducing alcohol intake and preventing alcohol relapse. Rats selectively bred for alcohol preference (alcohol preferring or "P" line) have enhanced responsiveness to the low dose reinforcing effects of alcohol, less aversion to moderate/high doses of alcohol, and are able to develop tolerance to the aversive effects of alcohol more rapidly and to maintain tolerance longer than rats selectively bred for alcohol nonpreference (alcohol nonpreferring or "NP" line). The increased potency of low-dose alcohol as a reinforcer for P rats might be expected to foster and maintain alcohol drinking. Weaker aversion to the pharmacological effects of moderate/high doses of alcohol in the P line would allow P rats to drink more alcohol than NP rats before the postingestional effects become aversive. Rapid induction of tolerance to the aversive effects of alcohol with repeated bouts of voluntary alcohol drinking, as well as persistence of alcohol tolerance in rats of the P line might serve to maintain alcohol drinking. These are powerful mechanisms that may serve to promote and maintain a high alcohol drinking behavior. Although these rat lines have been used to address several characteristics of excessive alcohol consumption in humans, they have not yet been used to model several aspects of human alcohol use disorders. New applications of these selectively bred rat lines are discussed which may further our understanding of the factors contributing to alcohol abuse and alcoholism.

show abstract

Pain Thresholds in Alcohol Preferring and Non‐preferring Rats: Diurnal and Repeated Trial Line Differences

Cited by 7 publications

References 44 publications

Predictors of Pain Severity 3 Months after Serious Injury

Predictors of Pain Severity 3 Months after Serious Injury

Alcohol dependence as a chronic pain disorder

What Aspects of Human Alcohol Use Disorders Can Be Modeled Using Selectively Bred Rat Lines?

Contact Info

Product

Resources

About