Pain Tolerance and Pain Perception in Adolescents Born Extremely Preterm

Vederhus, Bente Johanne; Eide, Geir Egil; Natvig, Gerd Karin; Markestad, Trond; Graue, Marit; Halvorsen, Thomas

doi:10.1016/j.jpain.2012.07.008

Cited by 33 publications

(57 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two attempts were made to contact the corresponding author of each paper where data was missing. Based on author responses, two articles that had originally been included in the review [11,103]were excluded, as it was revealed that the sample fell outside of the 0-18 year old age range. This resulted in a final total of 80 articles included, reporting on 81 separate studies, as one article reported on two studies with separate samples [109].…”

Section: Search Methodsmentioning

confidence: 99%

Sex differences in experimental pain among healthy children: A systematic review and meta-analysis

Boerner

Birnie

Caes

et al. 2014

Pain

108

View full text Add to dashboard Cite

Sex differences in response to experimental pain are commonly reported in systematic reviews in the adult literature. The objective of the present research was to conduct a systematic review and meta-analysis of sex differences in healthy children's responses to experimental pain (e.g., cold pressor, heat pain, pressure pain) and, where possible, to conduct analyses separately for children and adolescents. A search was conducted of electronic databases for published papers in English of empirical research using experimental pain tasks to examine pain-related outcomes in healthy boys and girls between 0 and 18 years of age. Eighty articles were eligible for inclusion and were coded to extract information relevant to sex differences. The systematic review indicated that, across different experimental pain tasks, the majority of studies reported no significant differences between boys and girls on painrelated outcomes. However, the meta-analysis of available combined data found that girls reported significantly higher pain intensity compared to boys in studies where the mean age of participants was greater than 12 years. Additionally, a meta-analysis of heat pain found that boys had significiantly higher tolerance than girls overall, and boys had significantly higher heat pain threshold than girls in studies where the mean age of participants was 12 years or younger. These findings suggest that developmental stage may be relevant for understanding sex differences in pain . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 SEX DIFFERENCES IN EXPERIMENTAL PAIN IN CHILDREN AbstractSex differences in response to experimental pain are commonly reported in systematic reviews in the adult literature. The objective of the present research was to conduct a systematic review and meta-analysis of sex differences in healthy children's responses to experimental pain (e.g., cold pressor, heat pain, pressure pain) and, where possible, to conduct analyses separately for children and adolescents. A search was conducted of electronic databases for published papers in English of empirical research using experimental pain tasks to examine pain-related outcomes in healthy boys and girls between 0 and 18 years of age. Eighty articles were eligible for inclusion and were coded to extract information relevant to sex differences. The systematic review indicated that, across different experimental pain tasks, the majority of studies reported no significant differences between boys and girls on pain-related outcomes. However, the meta-analysis of available combined data found that girls reported significantly higher pain intensity compared to boys in studies where the mean age of participants was greater than 12 years. Additionally, a meta-analysis of heat pain found that boys had significiantly higher tolerance than girls overall, and...

show abstract

Section: Search Methodsmentioning

confidence: 99%

Sex differences in experimental pain among healthy children: A systematic review and meta-analysis

Boerner

Birnie

Caes

et al. 2014

Pain

108

View full text Add to dashboard Cite

show abstract

“…There is experimental evidence in rodent studies for persistent changes in nociceptive processing and response to future pain following early life pain and injury [1]. Moreover, children born very preterm display altered pain thresholds [2,3,4], as well as exaggerated cortical activation in response to noxious stimulation [5]. Exposure to a greater number of neonatal painful interventions is associated with less endogenous pain inhibition during experimental pain in children born preterm, showing long lasting altered pain processing [6].…”

Section: Introductionmentioning

confidence: 99%

Neonatal Invasive Procedures Predict Pain Intensity at School Age in Children Born Very Preterm

Valeri

Ranger

Chau

et al. 2016

The Clinical Journal of Pain

View full text Add to dashboard Cite

Children born very preterm display altered pain thresholds. Little is known about neonatal clinical and psychosocial factors associated with their later pain perception. OBJECTIVE We aimed to examine whether the number of neonatal invasive procedures, adjusted for other clinical and psychosocial factors, was associated with self-ratings of pain during a blood collection procedure in children born very preterm at school age. METHODS 56 children born very preterm (24–32 weeks gestational age) at age 7.5 years, followed longitudinally from birth, and free of major neurodevelopmental impairments, underwent a blood collection by venipuncture. The children’s pain was self-reported using the Coloured Analog Scale and Facial Affective Scale. Parents completed the Child Behavior Checklist and State-Trait Anxiety Inventory. Pain exposure (number of invasive procedures) and clinical factors from birth to term-equivalent age were obtained prospectively. Multiple linear regression was used to predict children’s pain self-ratings from neonatal pain exposure after adjusting for neonatal clinical and concurrent psychosocial factors. RESULTS Greater number of neonatal invasive procedures and higher parent trait-anxiety were associated with higher pain intensity ratings during venipuncture at age 7.5 years. Fewer surgeries and lower concurrent child externalizing behaviors were associated with higher pain intensity. CONCLUSION In very preterm children, exposure to neonatal pain was related to altered pain self-ratings at school age, independent of other neonatal factors. Neonatal surgeries and concurrent psychosocial factors were also associated with pain ratings.

show abstract

“…C: In early adulthood (17-18 years), a more intense and prolonged thermal stimulus identifies increased sensitivity in subjects born preterm (mean gestational age 26.8 weeks) versus term-born control subjects. Tolerated duration of immersion of the hand in an ice and water bath (0-2 0 C) is represented as Kaplan-Meier curves representing 'survival' to a ceiling time of 180 seconds [198]. Reproduced with permission.…”

Section: Discussionmentioning

confidence: 99%

“…[83] In addition, fewer EP adolescents tolerated a cold pressor test, with earlier withdrawal of the hand from an ice water bath (Fig. 2C) [198]. Longitudinal evaluation at 19 years in the EPICure cohort, encompassing a range of outcomes to assess cognitive, behavioral and health outcomes [49] has recently been completed, and data from current pain and a comprehensive QST protocol is currently being analyzed.…”

Section: Analgesia and Sedation In Nicumentioning

confidence: 99%

Translational studies identify long-term impact of prior neonatal pain experience

Walker

2017

Pain

View full text Add to dashboard Cite

Pain Tolerance and Pain Perception in Adolescents Born Extremely Preterm

Cited by 33 publications

References 53 publications

Sex differences in experimental pain among healthy children: A systematic review and meta-analysis

Sex differences in experimental pain among healthy children: A systematic review and meta-analysis

Neonatal Invasive Procedures Predict Pain Intensity at School Age in Children Born Very Preterm

Translational studies identify long-term impact of prior neonatal pain experience

Contact Info

Product

Resources

About