Background: The etiological diagnosis of painful primary total hip arthroplasty and its
management is a complex clinical challenge for pain physicians. Extrinsic sources of pain in the hip
joint might be efficiently treated by clinical pain units, although the topic remains controversial.
Objectives: To conduct a literature review and suggest an evidence-based algorithmic approach
to managing painful hip arthroplasty.
Study Design: Systematic literature review with qualitative data synthesis.
Methods: We conducted an online search of Medline/Pubmed, Embase, Clinical Trials, and
Cochrane database using the Medical Subject Heading (MeSH) and free terms on all biomedical
literature published up to August 2019. Articles that described either the etiologies and management
of painful primary total hip arthroplasty or the imaging techniques to specifically assess any of its
causes were included. We collected the demographic data (gender, age, body mass index), main
etiologies, diagnostic tests, and specific treatments applied in each study. Based on the reviewed
evidence, we propose an algorithmic approach, with a special emphasis on etiologies that should
be referred to pain clinics.
Results: Twenty-four studies were included for the synthesis, 16 of which were observational
studies and 8 of which were non-systematic literature reviews that described a wide range of
etiologies of painful primary total hip arthroplasty. The results showed that 2/3 of the causes of
pain were intrinsic and need to be managed by orthopedic surgeons. One third of the etiologies
were extrinsic and should be referred to pain clinics once intrinsic causes have been ruled out.
Among extrinsic sources of pain, the most frequent was myofascial etiology.
Limitations: A publication bias might have been present due to the inclusion of studies published
only in English, Spanish, and German. The included studies also had heterogeneous methodologies.
Conclusions: The current review suggests that painful hip arthroplasty is not a rare condition
in clinical practice. We systematically reviewed etiologies and various treatments published in
the literature and we suggest an algorithmic approach to management based on the available
evidence. This approach incorporates the evidence regarding our knowledge of the etiologies,
diagnosis, and management of chronic pain after total hip arthroplasty.
Systematic review registration: The protocol was registered in PROSPERO the international
prospective register of systematic reviews, ID CRD42020185663.
Key words: Chronic pain, review, pain management, arthroplasty, hip replacement