Painful legs and moving toes

Painless legs and moving toes: Symptom reduction during pregnancy

“…3 NAA serum levels were on average 0.084 6 0.013 lmol/L in controls and 0.65 6 0.15 lmol/L in HD (t test: 5, P ¼ .00001). Patients taking drugs did not display different NAA levels compared to drug-free patients (t test: 0.65, n.s.).…”

“…1 A gas chromatography-mass spectrometry (GC-MS) method demonstrated the validity of NAA measurements in biological fluids in patients with neurological diseases. 2 Very recently, our group found that serum NAA, measured by liquid chromatography-MS (LC-MS), was significantly reduced in healthy controls with advancing age 3 and was increased in neurodegenerative and demyelinating diseases such as amyotrophic lateral sclerosis and multiple sclerosis. 4,5 The aim of our study was to evaluate NAA serum levels in a cohort of genetically confirmed HD patients.…”

“…3 We describe a woman with painless legs and moving toes, whose symptoms dramatically varied in relation to her menstrual cycle, oral hormone use, and pregnancy.…”

“…7 The mysterious nature of painless legs and moving toes further complicates the interpretation of our observation, given the variety of conditions that have been associated with this syndrome. 3 Painful legs and moving toes is commonly associated with peripheral nervous system lesions. However, peripheral nerve symptoms are only known to worsen (e.g., carpal tunnel syndrome), not improve, with pregnancy.…”

Spinal Stimulation for Movement Disorders

“…Painful Leg and moving toes (PLMT) is a rare syndrome characterized by leg pain, frequently with neurogenic features, associated with involuntary movement of toes [35,36]; it affects one or both legs and can also involve the upper limbs. The pathophysiology of PLMT entity is unknown.…”