Painless photodynamic therapy for facial actinic keratoses: A retrospective cohort study of the post-treatment inflammatory response

Shen, Alan S.; Heusinkveld, Lauren E.; Updyke, Abigail; Nowacki, Amy S.; Warren, Christine B.; Maytin, Edward V.

doi:10.1016/j.pdpdt.2023.103838

Cited by 2 publications

(1 citation statement)

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“…Being the part with the lower wavelength, blue light has a high energy content, which is useful in the skin photodynamic therapy of some pathologies, as in facial actinic keratosis. In this skin condition, the exposure of the photosensitizer protoporphyrin IX to blue light induces the generation of ROS and immunogenic cell death (ICD), a form of regulated cell death that triggers an immune response against the dying cells [90]. This generates an inflammatory response that helps to reduce the precancerous lesions, which are a typical hallmark of this pathology.…”

Section: Ficz and Blue Lightmentioning

confidence: 99%

Light Sensing beyond Vision: Focusing on a Possible Role for the FICZ/AhR Complex in Skin Optotransduction

Guarnieri

2024

Cells

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Although our skin is not the primary visual organ in humans, it acts as a light sensor, playing a significant role in maintaining our health and overall well-being. Thanks to the presence of a complex and sophisticated optotransduction system, the skin interacts with the visible part of the electromagnetic spectrum and with ultraviolet (UV) radiation. Following a brief overview describing the main photosensitive molecules that detect specific electromagnetic radiation and their associated cell pathways, we analyze their impact on physiological functions such as melanogenesis, immune response, circadian rhythms, and mood regulation. In this paper, we focus on 6-formylindolo[3,2-b]carbazole (FICZ), a photo oxidation derivative of the essential amino acid tryptophan (Trp). This molecule is the best endogenous agonist of the Aryl hydrocarbon Receptor (AhR), an evolutionarily conserved transcription factor, traditionally recognized as a signal transducer of both exogenous and endogenous chemical signals. Increasing evidence indicates that AhR is also involved in light sensing within the skin, primarily due to its ligand FICZ, which acts as both a chromophore and a photosensitizer. The biochemical reactions triggered by their interaction impact diverse functions and convey crucial data to our body, thus adding a piece to the complex puzzle of pathways that allow us to decode and elaborate environmental stimuli.

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Section: Ficz and Blue Lightmentioning

confidence: 99%