Paired Electrolysis-Enabled Arylation of Quinoxalin-2(1H)-ones

Abstract

The first paired electrolysis-enabled arylation of quinoxalin-2(1H)-ones was achieved using cyanoarenes as the arylation reagents. A variety of 3-arylquinoxalin-2(1H)-ones with various important functional groups were obtained in moderate to good yields under metal-and chemical oxidant-free conditions. With a pair of reductive and oxidative processes occurring among the substrates and reaction intermediates, the power consumption can be dramatically reduced.

Photocatalyzed Acylation of Azauracil Derivatives with Aldehydes

“…In recent years, the functionalization of N-heterocycles has become a crucial focus in modern drug discovery and development endeavors . By utilizing methods to functionalize N-heterocycles, researchers can greatly expand the structural variety of these compounds, leading to the discovery of novel bioactive molecules through innovative synthetic routes .…”