Pairing tone trains with vagus nerve stimulation induces temporal plasticity in auditory cortex

Shetake, Jai A.; Vrana, Will A.; Wolf, Jordan T.; Kilgard, Michael P.

doi:10.1016/j.expneurol.2011.10.026

Cited by 77 publications

(78 citation statements)

References 47 publications

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“…27 Additionally, pairing VNS with tones substantially reorganizes primary auditory cortex. 15,28 This enhanced plasticity in event-related neural circuitry is likely the mechanism that supports VNS-dependent recovery seen in this study as well.…”

supporting

confidence: 74%

Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Pruitt

Schmid

Kim

et al. 2016

Journal of Neurotrauma

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127

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Traumatic Brain Injury (TBI) is one of the largest health problems in the United States, and affects nearly 2 million people every year. The effects of TBI, including weakness and loss of coordination, can be debilitating and last years after the initial injury. Recovery of motor function is often incomplete. We have developed a method using electrical stimulation of the vagus nerve paired with forelimb use by which we have demonstrated enhanced recovery from ischemic and hemorrhagic stroke. Here we have tested the hypothesis that vagus nerve stimulation (VNS) paired with physical rehabilitation could enhance functional recovery after TBI. We trained rats to pull on a handle to receive a food reward. Following training, they received a controlled-cortical impact (CCI) in the forelimb area of motor cortex opposite the trained forelimb, and were then randomized into two treatment groups. One group of animals received VNS paired with rehabilitative therapy, whereas another group received rehabilitative therapy without VNS. Following CCI, volitional forelimb strength and task success rate in all animals were significantly reduced. VNS paired with rehabilitative therapy over a period of 5 weeks significantly increased recovery of both forelimb strength and success rate on the isometric pull task compared with rehabilitative training without VNS. No significant improvement was observed in the Rehab group. Our findings indicate that VNS paired with rehabilitative therapy enhances functional motor recovery after TBI.

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supporting

confidence: 74%

Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Pruitt

Schmid

Kim

et al. 2016

Journal of Neurotrauma

Self Cite

127

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“…Interleaved low-frequency tones that were not paired with VNS did not exhibit an increased response, suggesting VNS can label temporally specific stimuli. In addition to the changes in spectral response properties, VNS can also enhance temporal response characteristics of neurons in the primary auditory cortex [34]. Presentation of rapid trains of tones paired with VNS increased the maximal following rate of neurons within primary auditory cortex compared with naïve controls, while presentation of slow trains of tones paired with VNS decreased maximal following rate.…”

Section: Enhancing Plasticity With Vns Vns Paired With Tones Drives Rmentioning

confidence: 99%

“…As detailed above, VNS paired with tones can drive specific plasticity to alter spectral and temporal response characteristics of central auditory neurons [32,34]. If map distortion and alterations in receptive field size contribute to tinnitus, in principle, VNS paired with the appropriate presentation of tones could drive plasticity to restore the normal characteristics of the circuitry and alleviate the percept of tinnitus ( Fig.…”

Section: Preclinical and Clinical Studies For Tinnitusmentioning

confidence: 99%

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Hays

2016

Neurotherapeutics

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Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one such potential targeted plasticity therapy. Vagus nerve stimulation (VNS) drives activation of neuromodulatory nuclei that are associated with plasticity, including the cholinergic basal forebrain and the noradrenergic locus coeruleus. Repeatedly pairing brief bursts of VNS sensory or motor events drives robust, event-specific plasticity in neural circuits. Animal models of chronic tinnitus, ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and post-traumatic stress disorder benefit from delivery of VNS paired with successful trials during rehabilitative training. Moreover, mounting evidence from pilot clinical trials provides an initial indication that VNS-based targeted plasticity therapies may be effective in patients with neurological diseases and injuries. Here, I provide a discussion of the current uses and potential future applications of VNS-based targeted plasticity therapies in animal models and patients, and outline challenges for clinical implementation.

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“…27 Recently a new hypothesis has been raised. It supposes that targeted cortical plasticity can be obtained by pairing vagal stimulation (producing task non-specific modality afferent information only) with a second stimulation (producing task specific modality afferent information) [28][29][30][31][32] (See a recent review by Hays et al, 2013 33 ). In order to enhance cortical plasticity it is important that the vagal stimulation and the sensory or motor event are paired in time precisely.…”

Section: Eeg Measures During Ec Seriesmentioning

confidence: 99%

Effects of Acute Transcutaneous Vagal Stimulation on the EEG Power Maps, EEG Sources Distribution and Steadiness of Quiet and Sensory-conflicted Stance

Dimitrov¹,

Gatev²

2015

Posture, Balance and the Brain

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Transcutaneous vagal stimulation (t-VNS) is a prospective method as a cheap and noninvasive alternative of surgical cervical vagal stimulation widely used for treatment of refractory epilepsy, depression etc. Data on its application in healthy people are scarce. A lot of problems concerning the acting mechanisms and cortical representation are unsolved. We did acute t-VNS and studied the standing balance steadiness, EEG absolute power maps and sources distribution. We found improvement of the steadiness of standing with eyes open (EO), but no changes in the eyes closed (EC) series.In EO Delta and Theta power in the right frontal area increased and Beta and Gamma bands of EEG absolute power in the left and right parieto-occipital areas also increased, which sustained for 20 min after t-VNS. The distribution of maxima of EEG sources revealed by LORETA showed shifts to the right and occipital direction after t-VNS, while 20 min later the maxima were symmetrically located, but the occipital shift was preserved. Pre-treatment sources during EO were in multisensory fields: the inferior parietal lobule, superior temporal gyrus and precuneus, after t-VNS they were in the inferior parietal lobule, middle temporal gyrus, right posterior cingulate, precuneus, cuneus and right lingual gyrus. After 20 min the maxima of EEG sources were in the inferior parietal lobule, superior and middle temporal gyrus and left insula.In EC following t-VNS Delta power first decreased in the right frontal and occipital areas and in the central parietal area, 20 min later it was greater than in pre-treatment series in these areas. The results showed an increase of EEG absolute power in the Beta and Gamma ranges mainly in the occipital area and less expressed in the postero-parietal one. The increase was more expressed for Gamma than Beta band similarly to the EO series. However, this increase in Beta and Gamma EEG power in EC was mainly located in the left side of the cortex. After t-VNS we observed shifts of electrical sources locations to the occipital and top parts of the brain. Unlike, during the EO series we observed shift to the lower frequencies in the absolute power cortical maps. After 20 min a tendency to return to the pre-treatment coordinates occurred, the power, increased immediately after t-VNS, dropped much lower than its initial value. The locations of maxima of electrical sources during EC before t-VNS were in the middle and inferior frontal gyrus, right inferior parietal lobule, cingulate and precuneus. Immediately after t- Bozhidar Dimitrov and Plamen Gatev 46VNS these locations were in the superior temporal gyrus, middle temporal gyrus, precuneus, cuneus and left inferior parietal lobule. After 20 min the locations of the maxima of electrical sources were in the anterior cingulate cortex, medial frontal gyrus, precuneus, cuneus and lingual gyrus.Our results show that cortical processing of the t-VNS information and its effect on standing balance are quite different during standing with EO compared to standing with...

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Pairing tone trains with vagus nerve stimulation induces temporal plasticity in auditory cortex

Cited by 77 publications

References 47 publications

Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Effects of Acute Transcutaneous Vagal Stimulation on the EEG Power Maps, EEG Sources Distribution and Steadiness of Quiet and Sensory-conflicted Stance

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