Pal, a New Inherited Alpha‐2‐Globulin of Human Serum

Abstract

Summary The alpha‐2‐globulin previously reported as 'PAG' has been renamed Pa 1. It appears to be inherited by means of an autosomal gene, possibly recessive. There is no evidence indicating a genetic relation to 16 other independent grouping systems. The appearance of this protein seems to be under hormonal control. Résumé L'alpha‐2‐globuline précédemment appelée »PAG« a été renommée Pa 1. Il semble que cette alpha‐2‐globuline soit conditionnée par un gène autosomal, peut‐être récessif. Il n'y a aucune manifestation permettant de déduire qu'il y ait une relation génétique avec 16 autres systèmes de groupes indépendents. Cette protéine semble être sous contrôle hormonal. Zusammenfassung Das früher als »PAG« bezeichnete Alpha‐2‐Globulin wird in Pa 1 umbenannt. Es handelt sich offensichtlich um ein autosomales, möglicherweise rezessives Erbmerkmal. Es fehlen Hinweise für eine genetische Beziehung zu 16 anderen gruppen‐spezifischen Merkmalen. Das Auftreten dieses Eiweißes steht offenbar unter hormonaler Kontrolle.

Three Pregnancy-Associated Human Plasma Proteins: Purification, Monospecific Antisera and Immunological Identification

“…B ohn [2] as well as Hofmann et al [22] have shown that the 'pregnancy zone' protein detected by starch or acrylam ide gel electrophoresis [1,[23][24][25] is identical with SP3 as well as the Xh protein [26][27][28]. Another pregnancy-associated protein called PAG or Pal [29,30] was also identified as the Xh protein [27]. These data thus indicate that the 'pregnancy zone', SP3, a2-pregnoglobulin, Xh protein, and PAG (Pal) all represent one and the same pregnancy-associated protein, which is also detectable in some normal nonpregnant individu als.…”

Measurement of Pregnancy-Associated Plasma Proteins during Human Gestation

“…Analogous PAPP's were also found in the rat and mouse, although there was little or no immunological relationship between these proteins of the three species (4). Other investigators have also described various pregnancy-associated proteins in man by employing several assay methods and/or reagents (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”

Pregnancy-associated globulin body fluids of pregnant women.

“…These are called pregnancy-associated globulin (PAG), which is recognized immunoelectrophoretically in alpha 2 globulin region. PAG is not unique in pregnancy, and it is found also in malignant diseases (Stimson 1975a, b) and sometimes in normal females and males (MacLaren et al 1966;Kasukawa 1973;Sagisaka and Takahashi 1976). However, PAG in body fluids such as saliva, urine and amniotic fluid has not been reported.…”