2023
DOI: 10.21203/rs.3.rs-3312459/v1
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PAL inhibits foam cell formation by regulating the PPAR-γ signaling pathway in oxidized low-density lipoprotein-induced THP-1 macrophages

Siming Li,
Xinhang Jia,
Haoyang Mao
et al.

Abstract: Atherosclerotic cardiovascular disease continues to pose a major threat to human health. It has been shown that Chinese herbal medicines rich in palmatine(PAL) exert significant beneficial effects on atherosclerosis(AS). However, the specific biological functions and mechanisms of PAL in AS remain unclear. In this study, we investigated the effects of PAL on the core pathological changes in macrophage foam cell formation, a key process in the development of AS. The results demonstrated that PAL significantly r… Show more

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