The study was conducted in Abergelle district of Tigray, northern Ethiopia with the objectives of evaluating the chemical composition, in vitro dry matter digestibility (IVDMD) and in sacco degradability characteristics of foliages of major browse species. Samples of foliages from 12 and 10 browse species were collected during the wet and dry seasons, respectively. The samples of the browse species were collected based on their abundance in the district, preference by livestock to browse them, accessibility to browsing and their additional uses other than livestock feed. The neutral detergent fiber (NDF) was higher in the browse species during the wet compared to the dry season except for Sterculia africana and Ziziphus spina-christi. Similar trends were observed for acid detergent fiber (ADF) content except for Acacia asak. The condensed tannins content and the IVDMD of the browse species had inverse relationships in both seasons. The in sacco dry matter (DM) and nitrogen degradability parameters of the browse species were seasonally variable. Based on in sacco potential DM and nitrogen degradation of the browse species in both seasons, Acacia oerfota, Acacia tortilis, Balanites aegyptiaca, Boswellia papyrifera, Sterculia africana, Terminalia brownii and Ziziphus spina-christi were ranked to be superior in their nutritive value, and thus can have better use as animal feeds. Consequently, these browse species could be considered in agro-forestry systems for better integration of livestock production with available feed resources in semi-arid areas.