Palatal biopsy as a diagnostic aid in the study of connective tissue diseases

Eisenbud, Leon; Platt, Norbert; Stern, Martin; D’Angelo, William; Sumner, Philip

doi:10.1016/0030-4220(73)90029-7

Cited by 30 publications

(18 citation statements)

References 7 publications

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“…Later, focal lymphocytic sialadenitis was demonstrated in 82% of palatal biopsies from 80 patients with various CTDs, and in 6% from 80 ostensibly healthy patients to whom no exclusionary criteria had been applied (35). In another study, when LSG hiopsies from 86 patients were graded by qualitative criteria, more and larger aggregates of lymphocytes and plasma cells were observed in patients with SS than in those with both SS and RA (36).…”

Section: Discussionmentioning

confidence: 98%

Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

501

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Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjögren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS), and other connective tissue diseases (CTD). LSG biopsy focus scores of >1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease‐specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.

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Section: Discussionmentioning

confidence: 98%

Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

501

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“…Unlike the wide range of studies carried out on the focal lymphocytic infiltrates (FLI) in LSG, only a few have been conducted on the palatal salivary glands (PSG) (7,8). The presence of lymphocytic infiltrates in aging PSG from healthy subjects has not been evaluated.…”

mentioning

confidence: 99%

Focal lymphocytic infiltration in aging human palatal salivary glands: a comparative study with labial salivary glands

Vered

Buchner

Haimovici

et al. 2001

J Oral Pathology Medicine

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Investigation of age-related prevalence of various types of focal lymphocytic infiltration (FLI) and degrees of histomorphologic changes was conducted on 120 biopsies of palatal and labial salivary glands (PSG and LSG, respectively) obtained from autopsy subjects free of salivary gland tumors/diseases. Biopsies were divided into young (<30 years, n=30), adult (30-60 years, n=45) and old (>60 years, n=45) age groups. A modified Chisholm & Mason grading system was used to record grades of FLI and a modified Greenspan et al. system was used to evaluate the severity of histomorphologic changes. The prevalence of FLI in PSG increased significantly from 10% in the young group to 46.6% in the old group (P=0.0012). No significant changes were found with aging in LSG. FLI was significantly more prevalent in the adult and old age groups in PSG as compared with LSG (P=0.015 and P=0.003, respectively). Both glands demonstrated significant histomorphologic changes among age groups (p<0.0001); however, these changes were significantly less common in the old age group in PSG as compared to LSG (P=0.003). In cases showing severe histomorphologic changes, FLI was not present. Therefore, FLI should not be considered as part of the deteriorating histomorphologic changes that are usually encountered in salivary glands with aging. The immunologic profile of these infiltrates should be further clarified to understand their role, both in physiologic and pathologic conditions.

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“…Typical periductal aggregations of mononuclear cells, reported in major salivary glands of the MRL/1 mice, were not found in our study. In SS, the human palatal (39)(40)(41)(42) and buccal salivary glands (43) show the same pattern of inflammatory infiltrates as the major salivary glands. That buccal and palatine salivary glands are spared by the infiammatory process may illustrates the heterogeneity already observed in submandibuiar, parotid and sublingual glands (11).…”

Section: Discussionmentioning

confidence: 98%

The oral mucosa of the MRL/I mouse: a synoptic picture of systemic autoimmune disorders

Barbeau

Deslauriers

1991

J Oral Pathology Medicine

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The oral manifestations of systemic autoimmunity were investigated in a kinetic study of the MRL/1 mouse. Lesions in the epithelium, connective tissue and minor salivary glands were characterized in serial sections of the soft palate and the cheeks with respect to 1) the type of inflammatory cells present, 2) the presence and type of vasculitis, 3) the presence of necrosis, 4) the occurrence of deposits. By the age of 16 wk, 100% of our animals had developed mild to severe lesions in at least one compartment of the mucosa. Between 16 and 32 wk of age, pathologic manifestations affected the epithelial and subepithelial tissues, the striated muscle tissue, the vascular system and, much less frequently, the minor salivary gland network.

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Palatal biopsy as a diagnostic aid in the study of connective tissue diseases

Cited by 30 publications

References 7 publications

Labial salivary gland biopsy in sjögren's syndrome

Labial salivary gland biopsy in sjögren's syndrome

Focal lymphocytic infiltration in aging human palatal salivary glands: a comparative study with labial salivary glands

The oral mucosa of the MRL/I mouse: a synoptic picture of systemic autoimmune disorders

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