Palatine tonsillar metastasis of rectal adenocarcinoma: a case report and literature review

Wang, Hao; Chen, Ping

doi:10.1186/1477-7819-11-114

Cited by 14 publications

(19 citation statements)

References 23 publications

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“…The palatine tonsil does not have any afferent lymphatics so any metastasis in a tonsil originates from hematogenous spread, hence implying a poor prognosis . In the human literature, only 0.8% of tonsillar malignancies result from metastasis of nonhematological malignant neoplasm . Bilateral thyroid gland invasion was suspected in case 10.…”

Section: Discussionmentioning

confidence: 96%

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Computed tomographic appearance of canine tonsillar neoplasia: 14 cases

Thierry

Longo

Pecceu

et al. 2017

Vet Radiology Ultrasound

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The palatine tonsil is an uncommon site of oral canine neoplasia. For affected tonsils, squamous cell carcinoma is the most frequent type of neoplasia, followed by melanoma and lymphoma. Computed tomography (CT) is increasingly used for investigation of canine oropharyngeal pathology; however, limited information is available on the CT appearance of tonsillar neoplasms. Objectives of this retrospective descriptive case series were to characterize the CT features of canine tonsillar neoplasia and determine whether specific CT features differentiate nonneoplastic from neoplastic tonsils. Computed tomographic studies of 14 dogs diagnosed with tonsillar neoplasia were retrieved from two referral hospitals and reviewed by two observers. Diagnosis was based on histology or cytology. Carcinoma was diagnosed in 11 dogs, melanoma in two and lymphoma in one dog. Specific CT features of the tonsil and regional lymph nodes did not differentiate neoplastic from nonneoplastic tonsillar diseases, but regional lymph node CT features were useful for diagnosis in some cases. Marked enlargement (width ≥ 18 mm, 12/18), heterogeneity (16/18), and loss of the hypoattenuating hilus (18/18) of the medial retropharyngeal lymph node were common concomitant features of tonsillar neoplasia. The medial retropharyngeal and mandibular lymphadenomegaly was ipsilateral to the neoplastic tonsil in 8/12 and 6/9 dogs, respectively. Five dogs demonstrated little or no enlargement of the tonsil despite the associated metastatic lymphadenomegaly. Tonsillar neoplasia should therefore be considered as a differential diagnosis for dogs with CT evidence of isolated medial retropharyngeal lymphadenomegaly (regardless of normally sized tonsils), or of any enlarged tonsil with no associated lymphadenomegaly.

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Section: Discussionmentioning

confidence: 96%

“…There is a smaller deeper portion that lies under the mucosa forming the lateral wall of the fossa that is usually only formed in pathologic conditions . Tonsillar enlargement can occur as a normal immune reaction to infectious stimuli, or as a primary or metastatic neoplasia …”

Section: Introductionmentioning

confidence: 99%

Computed tomographic appearance of canine tonsillar neoplasia: 14 cases

Thierry

Longo

Pecceu

et al. 2017

Vet Radiology Ultrasound

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“…6 This is the 12th reported case of colorectal cancer with tonsillar metastasis in English Literature. The presented case was clearly defined with physical finding, proper imaging methods and pathological features.…”

Section: Discussionmentioning

confidence: 92%

A case of rectal adenocarcinoma presented with palatine tonsil metastasis

Tonyali

Sümbül

Ozturk³

et al. 2014

J Oncol Pharm Pract

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The most common metastatic sites of colorectal cancer are liver, lung, peritoneum and lymph nodes. Metastasis of colorectal carcinoma to palatine tonsil is rarely seen. To our knowledge, only 11 patients were documented in English literature. Atypical metastases can sometimes lead to misdiagnosis. Precise diagnosis of atypical metastases requires a careful physical examination, good imaging method and comprehensive pathological evaluation. Here, we report a case of rectal adenocarcinoma presented with palatine tonsil metastasis.

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“…Batson postulated that the valveless vertebral venous plexus serves as a conduit for bypassing filtration through the lungs and the increase in intrathoracic pressure directs blood flow towards the head and neck region from the caval and azygos venous systems [ 8 ]. In a case report describing palatine tonsillar metastasis of rectal adenocarcinoma, Wang and Chen proposed a combination of hematogenous dissemination and retrograde cervical lymphatic spread through the thoracic duct to be responsible for metastasis to the oral cavity [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical staining, in conjunction with histopathology, helps aid in definitively differentiating a primary intraoral malignancy from a metastatic lesion with a distant primary tumor. Positive staining for cytokeratin 20 (CK20) suggests a gastrointestinal primary tumor, as most CRCs are positive for CK20 [ 9 ]. CK20 and the large bowel marker CDx-2 were both positive in our patient, suggesting the primary source of the tongue adenocarcinoma to be colorectal in origin.…”

Section: Discussionmentioning

confidence: 99%

Colorectal Adenocarcinoma Metastasis to the Tongue

Gill

Frattali

2015

Case Reports in Otolaryngology

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This case presentation examines a rare clinical entity: colorectal adenocarcinoma (CRC) metastasis to the tongue. CRC is among the least common tumors to metastasize to the oral cavity. Objectives for this case report are to (1) maintain a high index of suspicion for oral cavity tumors representing metastatic disease, (2) consider appropriate surgical and adjunctive interventions, and (3) recognize the significance of identifying the primary tumor via immunohistochemical staining. We present a case of a 57-year-old male with a history of stage IV rectal adenocarcinoma metastatic to the lung who presented to our clinic with a painful mass of the right lateral tongue that he noticed one month before. MRI of the neck revealed a mass involving the anterior two-thirds of the right tongue with irregular margins and an ipsilateral enlarged right jugulodigastric lymph node. The patient underwent right partial glossectomy with primary reconstruction and right modified radical neck dissection. Pathology confirmed poorly differentiated adenocarcinoma consistent with a colorectal primary with lymphovascular and perineural invasion. The tumor was staged as T2N1, and the patient was referred for chemoradiation. In this report, we discuss the presentation, diagnosis, and treatment of this uncommon disease, with a thorough review of the world literature.

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Palatine tonsillar metastasis of rectal adenocarcinoma: a case report and literature review

Cited by 14 publications

References 23 publications

Computed tomographic appearance of canine tonsillar neoplasia: 14 cases

Computed tomographic appearance of canine tonsillar neoplasia: 14 cases

A case of rectal adenocarcinoma presented with palatine tonsil metastasis

Colorectal Adenocarcinoma Metastasis to the Tongue

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