Palatopharyngoplasty with bilateral buccal mucosal graft repair to alleviate oropharyngeal stenosis

Tompkins, Jared J.; Vaughn, Cory A.; Shaikh, Faisal A.; Stocks, Rose Mary S.; Thompson, J. W.

doi:10.1016/j.ijporl.2015.06.022

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…For all of the above applications, buccal mucosa tissue is the most suitable donor tissue and represents the gold standard in most of these reconstructive applications (Chiapasco, Colletti, Romeo, Zaniboni, & Brusati, 2008;De Bree et al, 2008;de Trey & Morrison, 2013;Dhillon, Mohan, Raju, & Lakhanpal, 2013;Khan, Zaheer, & Gupta, 2013;Tompkins, Vaughn, Shaikh, Stocks, & Thompson, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the use of autologous tissue is often associated with severe complications at the initial surgical area such as pain, scar formation, strictures, and paresthesia (Almela, Brook, & Moharamzadeh, 2016;Heller et al, 2016;Markiewicz, Margarone, Barbagli, & Scannapieco, 2007;Moharamzadeh, Brook, van Noort, Scutt, & Thornhill, 2007;Mungadi & Ugboko, 2009). Since the success of an operative reconstruction is mainly determined by the size of adequate donor tissue for the tissue transfer (Tompkins et al, 2015), one of the major problems is the limited quantity of applicable donor tissue.…”

Section: Introductionmentioning

confidence: 99%

“…For all of the above applications, buccal mucosa tissue is the most suitable donor tissue and represents the gold standard in most of these reconstructive applications (Chiapasco, Colletti, Romeo, Zaniboni, & Brusati, ; De Bree et al, ; de Trey & Morrison, ; Dhillon, Mohan, Raju, & Lakhanpal, ; Khan, Zaheer, & Gupta, ; Tompkins, Vaughn, Shaikh, Stocks, & Thompson, ). However, disadvantages of autologous buccal mucosa are the limited access and quantity and make the wound coverage of large areas nearly impossible.…”

Section: Introductionmentioning

confidence: 99%

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The impact of intercellular communication for the generation of complex multicellular prevascularized tissue equivalents

Heller

Bauer

Schwab

et al. 2019

J Biomedical Materials Res

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In reconstructive surgery the use of prevascularized soft tissue equivalents is a promising approach for wound coverage of defects after tumor resection or trauma. However, in previous studies to generate soft tissue equivalents on collagen membranes, microcapillaries were restricted to superficial areas. In this study, to understand which factors were involved in the formation of these microcapillaries, the levels of the angiogenic factors vascular endothelial growth factor (VEGF), Interleukin-8 (IL-8), and basic fibroblast growth factor (bFGF) in the supernatants of the tissue equivalents were examined at various time points and conditions. Additionally, the influence of these factors on viability, proliferation, migration, and tube formation in monocultures compared to cocultures of fibroblast and endothelial cells was examined. The results showed that VEGF production was decreased in cocultures compared to fibroblast monocultures and the lowest VEGF levels were observed in endothelial cell monocultures. Additionally, the highest levels of IL-8 were observed in cocultures compared to monocultures. Similar results were observed for bFGF with lowest levels seen within the first 24 hr and highest levels in cocultures. VEGF and IL-8 were shown to promote endothelial cell viability, proliferation and migration and angiogenic parameters such as tube density, total tube length, and number of tube branches. Addition of VEGF and IL-8 to cocultures resulted in accelerated and denser formation of capillarylike structures. The results indicate that VEGF, IL-8, and bFGF strongly influence cellular behavior of endothelial cells and this information should be useful in promoting the formation of microcapillary-like structures in complex tissue equivalents. K E Y W O R D S angiogenic growth factors, coculture, HDMEC, intercellular communication, microvascular endothelial cells

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…For all of the above applications, buccal mucosa tissue is the most suitable donor tissue and represents the gold standard in most of these reconstructive applications (Chiapasco, Colletti, Romeo, Zaniboni, & Brusati, ; De Bree et al, ; de Trey & Morrison, ; Dhillon, Mohan, Raju, & Lakhanpal, ; Khan, Zaheer, & Gupta, ; Tompkins, Vaughn, Shaikh, Stocks, & Thompson, ). However, disadvantages of autologous buccal mucosa are the limited access and quantity and make the wound coverage of large areas nearly impossible.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of intercellular communication for the generation of complex multicellular prevascularized tissue equivalents

Heller

Bauer

Schwab

et al. 2019

J Biomedical Materials Res

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“…

have been reported for release of similar oropharyngeal and nasopharyngeal stricture patterns such as triamcinolone injection, manual dilation method, division and skin grafting, local flaps like pharyngeal or palatal mucosal flaps, and free flap techniques [3].

…”

mentioning

confidence: 99%

Pediatric Oronasopharyngeal Stricture– A Rare Surgical Complication of Adeno-Tonsillectomy Abstract

Shenoy

Samanth

Parvathareddy

et al. 2023

Indian J Otolaryngol Head Neck Surg

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Introduction: Oronasopharyngeal stricture is a rare sequel of oropharyngeal surgical procedure which can cause swallowing difficulty, dyspnea, sleep related breathing disorders, incompetence at the velopharynx due to soft palatal adherence. Case: Here we present a case of nine-year-old girl who presented to us with complains of nasal obstruction since 3 months and symptoms of sleep disordered breathing. She underwent adenotonsillectomy 5 years ago and coblator assisted palatoplasty and stricture release 4 months ago. On examination adenoid facies was noted, postpalatoplasty and tonsillectomy status with stricture between the anterior and posterior tonsillar pillars. Soft palate was stuck to posterior pharyngeal wall. Computed tomography scan was done which depicted homogenously enhancing soft tissue density causing complete nasopharyngeal airway obstruction. Oronasopharyngeal stricture release was performed under general anesthesia. Infant feeding tube was inserted through the nasal cavity and introduced through the oropharynx into exterior and was tied externally which was removed on postoperative day 5. Child is on regular follow up since 5 months and asymptomatic. Discussion: Oropharyngeal stricture is reported as a rare sequela of adenotonsillectomy. Many surgical techniques have been reported for release of similar oropharyngeal and nasopharyngeal stricture patterns such as triamcinolone injection, manual dilation method, plasma hook method, division and skin grafting, local flaps like pharyngeal or palatal mucosal flaps, and free flap techniques. Conclusion: Utmost care must be taken during the surgical procedure of oropharynx to prevent collateral damage to mucosal surfaces which can result in such devastating complications.

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Palatal eversion for the treatment of combined nasopharyngeal stenosis and tonsillar pillars adhesion

AbdelFattah

2016

International Journal of Pediatric Otorhinolaryngology

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Palatopharyngoplasty with bilateral buccal mucosal graft repair to alleviate oropharyngeal stenosis

Cited by 7 publications

References 8 publications

The impact of intercellular communication for the generation of complex multicellular prevascularized tissue equivalents

The impact of intercellular communication for the generation of complex multicellular prevascularized tissue equivalents

Pediatric Oronasopharyngeal Stricture– A Rare Surgical Complication of Adeno-Tonsillectomy Abstract

Palatal eversion for the treatment of combined nasopharyngeal stenosis and tonsillar pillars adhesion

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