Dietary, paleoclimatic, and ethnohistoric evidence indicates that alterations in regional systems of exploitation and selective pressures were associated with the diffusion of farming in unrelated periods of Southwestern and Great Basin cultural development. Artifacts and coprolite/macrofloral remains from the Clydes Cavern and Hogup Cave Fremont sites suggest that the spread of maize farming coincided with: (a) the development of grass collecting; (bj the expansion of a grassland environment; (c) outside cultural contacts; and (dj genetic modifications in corn. Ethnohistoric evidence indicates that the diffusion ofNuma horticulture in the early historic period also occurred in a context of environmental change. However, unlike the Fremont example in which natural environmental modifications were present, the spread of Numa farming occurred as a result of disruptions to the native plant communities and the seed gathering cycle caused by external cultural pressures. Both examples demonstrate that while the specific reasons for the adoption and growth of farming differed depending upon the regional situation, the overall pattern of horticultural diffusion in the Southwest and Great Basin may have been favored by selective pressures involving environmental alteration, population expansion and contact influences.