Palisading cutaneous fibrous histiocytoma

Schwob, Valerie S.; Cruz, Daniel J. Santa

doi:10.1111/j.1600-0560.1986.tb01083.x

Cited by 65 publications

(37 citation statements)

References 6 publications

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“…The fibrocollagenous type of dermatofibroma has a predominance of collagen and fibroblast-like cells in an irregular or whorled arrangement 18 . One variant of the fibrocollagenous type, the 'palisading dermatofibroma,' has nuclear palisading and prominent verocay-like bodies in part of the lesion 12 . The cases with a prominent storiform pattern are referred to as cellular dermatofibroma 3 .…”

Section: Discussionmentioning

confidence: 99%

“…However, many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid a misdiagnosis of a possibly more aggressive tumor. The main histologic variants include fibrocollagenous, cellular 3 , histiocytic 4 , lipidized 5 , angiomatous 6 , aneurysmal 7 , clear cell 8 , monster cell 9 , myxoid 10 , keloidal 11 , palisading 12 , osteoclastic 13 and epithelioid dermatofibroma 14 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

et al. 2011

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Background: Many variants of dermatofibromas have been described, and being aware of the variants of dermatofibromas is important to avoid misdiagnosis. Objective: We wanted to evaluate the clinical and pathologic characteristics of 122 cases of dermatofibromas. Methods: We retrospectively reviewed the medical records and 122 biopsy specimens of 92 patients who were diagnosed with dermatofibroma in the Department of Dermatology at Eulji Hospital of Eulji University between January 2000 and March 2010. Results: Nearly 80% of the cases occurred between the ages of 20 and 49 years, with an overall predominance of females. Over 70% of the lesions were found on the extremities. The most common histologic variant was a fibrocollagenous dermatofibroma (40.1%). Other variants included histiocytic (13.1%), cellular (11.5%), aneurysmal (7.4%), angiomatous (6.5%), sclerotic (6.5%), monster (4.9%), palisading (1.6%) and keloidal dermatofibromas (0.8%). There were 9 dermatofibromas (7.3%) that were the mixed type with two co-dominant histologic features. Conclusion: The results of this study are consistent with previous reports on the clinical features of dermatofibromas. However, we observed several characteristic subtypes of dermatofibroma and we compared the frequency of the histologic subtypes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

et al. 2011

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“…However, DF may show up in numerous disguises, which not only make the diagnosis more difficult but may mimic other benign and even malignant tumors. In the last few years, uncommon specific variants of DF with distinctive histologic features have been delineated including DF with monster cells [1], DF with palisading nuclei [2], with osteoclast-like giant cells [3], DF with clear cells [4], sclerotic [5], xanthomized [6], atrophic [7], fibrous DF [8]and the deep variant [9]. Among the histopathologic spectrum of this benign fibrohistiocytic proliferation, DF with granular cells represents a new histologic variant originally described by LeBoit and Barr [10]in 1991 of which only few cases have been reported in the literature [11, 12, 13, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

Dermatofibroma with Granular Cells: A Report of Two Cases

Aloi

Albertazzi²,

Pippione³

1999

Dermatology

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We describe two examples of an unusual variant of dermatofibroma (DF) in which areas of granular cells were a prominent feature. The diagnosis of DF was confirmed by immunohistochemistry and by ultrastructural studies. Granular cell changes can be observed in numerous benign and malignant cutaneous tumors of different cellular lineage. Cellular granularity is a nonspecific phenomenon characterized by intracytoplasmic accumulation of lysosomes and may cause diagnostic difficulties. Traumatic factors may be involved in the pathogenesis of cellular granularity.

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“…Several clinicopathological variants of DF have been described, including fibrocollagenous, vascular, angiomatoid, sclerosing, palisading, epithelioid cell histiocytoma and DF with monster cells [1, 2, 3, 18, 19, 20]. Myxoid DF is a very rare variant of DF, which is characterized by marked stromal mucin deposition.…”

Section: Discussionmentioning

confidence: 99%

Decreased CD44 Expression and Stromal Hyaluronate Accumulation in Myxoid Dermatofibroma

Çalıkoğlu

Chavaz²,

Saurat³

et al. 2003

Dermatology

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Background: Dermatofibroma (DF) is a common benign histiocytic tumor, which has several clinicopathological variants. Myxoid DF is one of these variants, which is characterized by a stromal mucin deposition. CD44 is a polymorphic transmembrane glycoprotein and the principal cell surface receptor of hyaluronate (HA), the major component of the extracellular matrix. In a recent study, we have observed an abnormal accumulation of HA in the superficial dermis of transgenic mice with a keratinocyte-specific CD44 expression defect. We have also shown that HA was accumulated in large amounts in the superficial dermis of lichen sclerosus et atrophicus (LSA) lesions and that the epidermal CD44 expression of LSA skin was significantly decreased or lost. In an another study, we have suggested that a decrease in CD44 expression in follicular epithelial proliferations might be correlated with an abnormal HA accumulation in perifollicular solitary cutaneous myxoma. Recently we have also demonstrated that classical DF lesions displayed a strong CD44 expression in tumor cells and a weak HA positivity in tumor stroma whereas CD44 expression was significantly reduced or absent in dermatofibrosarcoma lesions and the tumor stroma showed strong HA staining. Objective and Methods: Here we present 3 cases of myxoid DF, in which we explored the nature of the mucinous material in myxoid stroma by colloidal iron and hyaluronic acid binding protein stainings, as well as the expression of CD44 in the tumor cells by immunohistochemistry. Results: We show that HA is accumulated in the stroma of all myxoid DF lesions with a significant decrease in CD44 expression in the tumor cells. Conclusion: Our results suggest that a decrease in CD44 expression in the tumor cells may result in stromal myxoid changes characterized by an abnormal HA accumulation in myxoid DF.

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Palisading cutaneous fibrous histiocytoma

Cited by 65 publications

References 6 publications

A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

Dermatofibroma with Granular Cells: A Report of Two Cases

Decreased CD44 Expression and Stromal Hyaluronate Accumulation in Myxoid Dermatofibroma

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