Palladium alloys for biomedical devices

Wataha, John C.; Shor, Kavita

doi:10.1586/erd.10.25

Cited by 34 publications

(22 citation statements)

References 54 publications

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“…As Ni is a well‐known sensitizer, its use in biomedical devices is an issue of debate throughout many medical disciplines (18, 19). Lately, it has been suggested that Pd might be a safe alternative to Ni as an alloying metal in biomedical devices (20). However, the results of this study discourage this suggestion.…”

Section: Discussionmentioning

confidence: 64%

Sodium tetrachloropalladate for diagnosing palladium sensitization

et al. 2012

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Section: Discussionmentioning

confidence: 64%

Sodium tetrachloropalladate for diagnosing palladium sensitization

et al. 2012

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“…Wide use of metal in jewelry, coins, surgical instruments, and dental restorations may be responsible for recent increases in allergy incidence [3]. Furthermore, the occurence of allergic reactions to dental materials is poorly understood [2].…”

Section: Introductionmentioning

confidence: 99%

NKG2D+ IFN-γ+ CD8+ T Cells Are Responsible for Palladium Allergy

et al. 2014

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Nickel, cobalt, and chromium are well known to be causal agents of allergic contact dermatitis. Palladium (Pd) can also cause allergic disease and exposure results from wide use of this metal in dental restorations and jewelry. Metal allergy is categorized as a delayed-type hypersensitivity, and metal-responsive T cell clones have been isolated from allergic patients. However, compared to nickel, little is known about the pathology of allergic disease mediated by Pd, and pathogenic T cells are poorly understood. To identify the pathogenic T cells that are responsible for onset of Pd allergy, we enriched metal-responsive lymphocytes by sequential adoptive transfer of involved lymph node cells. Here we show that sequential adoptive transfer gradually increased the incidence and the intensity of Pd allergy, and CD8+ T cells are responsible for the disease as CD8+ T cell-depleted mice and β2-microglobulin-deficient mice did not develop Pd allergy. In addition, we found that draining lymph node cells skewed toward CD8+ T cells in response to Pd challenge in 8th adoptive transferred recipient mice. The CD8+ T cells expressed NKG2D, a costimulatory molecule involved in the production of IFN-γ. NKG2D ligand was also induced in Pd-injected tissues. Furthermore, both NKG2D ligand-transgenic mice, where NKG2D is downmodulated, and IFN-γ-deficient mice showed impaired Pd allergy. Taken together, these results indicate that IFN-γ-producing NKG2D+ CD8+ T cells are responsible for Pd allergy and suggest that NKG2D is a potential therapeutic target for treatment of metal allergy.

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“…In addition to nickel (Ni), cobalt (Co) and chromium (Cr), which often induce metal allergy, palladium (Pd) was also reported as a causal metal for allergic contact dermatitis. Dental materials containing Pd have increased because of its resistance to corrosion [2,3]. Therefore, metal allergy caused by Pd ions eluted from dental materials has become a serious problem [4].…”

Section: Introductionmentioning

confidence: 99%

Characterization of T Cell Receptors of Th1 Cells Infiltrating Inflamed Skin of a Novel Murine Model of Palladium-Induced Metal Allergy

et al. 2013

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Metal allergy is categorized as a delayed-type hypersensitivity reaction, and is characterized by the recruitment of lymphocytes into sites of allergic inflammation. Because of the unavailability of suitable animal models for metal allergy, the role of T cells in the pathogenesis of metal allergy has not been explored. Thus, we developed a novel mouse model for metal allergy associated with infiltration of T cells by multiple injections of palladium (Pd) plus lipopolysaccharide into the footpad. Using this model, we characterized footpad-infiltrating T cells in terms of phenotypic markers, T cell receptor (TCR) repertoires and cytokine expression. CD3+ CD4+ T cells accumulated in the allergic footpads 7 days after Pd challenge. The expression levels of CD25, interleukin-2, interferon-γ and tumor necrosis factor, but not interleukin-4 and interleukin-5, increased in the footpads after challenge, suggesting CD4+ T helper 1 (Th1) cells locally expanded in response to Pd. Infiltrated T cells in the footpads frequently expressed AV18-1 and BV8-2 T cell receptor (TCR) chains compared with T cells in the lymph nodes and exhibited oligoclonality. T-cell clones identified from Pd-allergic mouse footpads shared identical CDR3 sequences containing AV18-1 and BV8-2. These results suggest that TCR AV18-1 and BV8-2 play dominant and critical parts in the antigen specificity of Pd-specific Th1 cells.

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Palladium alloys for biomedical devices

Cited by 34 publications

References 54 publications

Sodium tetrachloropalladate for diagnosing palladium sensitization

Sodium tetrachloropalladate for diagnosing palladium sensitization

NKG2D+ IFN-γ+ CD8+ T Cells Are Responsible for Palladium Allergy

Characterization of T Cell Receptors of Th1 Cells Infiltrating Inflamed Skin of a Novel Murine Model of Palladium-Induced Metal Allergy

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