Palladium-catalysed hydroxylation and alkoxylation

Abstract

The formation of oxygen-carbon bonds is one of the fundamental transformations in organic synthesis. In this regard the application of palladium-based catalysts has been extensively studied during recent years. Nowadays it is an established methodology and the success has been proven in manifold synthetic procedures. This tutorial review summarizes the advances on palladiumcatalysed C-O bond formation, means hydroxylation and alkoxylation reactions.

Ohne dirigierende Gruppen: übergangsmetallkatalysierte C‐H‐Aktivierung einfacher Arene

“…[1g, 95] Bisher hat sich eine Vielzahl von Übergangsme-tallen, einschließlich Eisen [96] und Palladium, [84,97] als geeignete Katalysatoren für die direkte Hydroxylierung von Benzolderivaten erwiesen, allerdings lieferten diese nur geringe Umsätze und Regioselektivitäten. [98] Palladium(II)-acetat wurde zudem erfolgreich als Katalysator zur direkten Acetoxylierung von einfachen Arenen eingesetzt.…”

Purinyl N1-Directed Aromatic C–H Oxidation in 6-Arylpurines and 6-Arylpurine Nucleosides

“…2–4 Of relevance to this communication, a recent review has focused on Pd-catalyzed C–O bond formation. 5 …”

Directing group-assisted transition-metal-catalyzed vinylic C-H bond functionalization

“…Construction of C-O bonds via the oxidation of unactivated sp 2 C-H bonds constitutes one of the fundamental transformations in organic synthesis [29]. Alkoxylation and acetoxylation represent two forms of these C-O construction methods.…”