Palladium-catalyzed alkynylation of allylic <i>gem</i>-difluorides

Liu, Guo-ying; Tang, Lu-ning; Li, Jun-hua; Yang, Sen; Chen, Ming

doi:10.1039/d4cc01007h

Chem. Commun.

2024

DOI: 10.1039/d4cc01007h

|View full text |Cite

Palladium-catalyzed alkynylation of allylic gem-difluorides

Guo-ying Liu,

Lu-ning Tang,

Jun-hua Li

et al.

Abstract: Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic gem-difluorides via C-F bond activation/transmetallation/β-C elimination or reductive elimination have been achieved. This innovative protocol showcases an extensive substrate range...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Palladium-Catalyzed Double ipso-Defluoroetherification of Allylic gem-Difluorides with Phenols or Alcohols

Chen,

Tang,

Chen

2024

Org. Lett.

View full text Add to dashboard Cite

Significant progress has been made in the synthesis of diverse ketals through a palladium-catalyzed reaction involving allylic gem-difluorides and various phenols or alcohols. This methodology facilitates double ipso-defluoroetherification of allylic gem-difluorides, resulting in high product yields with excellent regioselectivity. The reactions were conducted under mild conditions and exhibited outstanding tolerance to a wide range of functional groups. Notably, this approach overcomes the traditional limitation of palladium-catalyzed processes, where nucleophiles typically target the common C-1 position of allylic gem-difluorides, enabling selective functionalization at the rare C-3 position instead.

show abstract

Palladium-Catalyzed Double ipso-Defluoroetherification of Allylic gem-Difluorides with Phenols or Alcohols

Chen,

Tang,

Chen

2024

Org. Lett.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Palladium-catalyzed alkynylation of allylic gem-difluorides

Abstract: Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic gem-difluorides via C-F bond activation/transmetallation/β-C elimination or reductive elimination have been achieved. This innovative protocol showcases an extensive substrate range...

Cited by 1 publication

References 52 publications

Palladium-Catalyzed Double ipso-Defluoroetherification of Allylic gem-Difluorides with Phenols or Alcohols

Palladium-Catalyzed Double ipso-Defluoroetherification of Allylic gem-Difluorides with Phenols or Alcohols

Contact Info

Product

Resources

About