Palladium‐Catalyzed Amide Directed Regioselective γ‐Alkenylation of Unactivated Alkenes with Vinylcyclopropanes

Abstract

Herein, we have demonstrated a palladium‐catalyzed γ‐alkenylation of unactivated alkenes with vinylcyclopropanes. A bidentate 8‐aminoquinoline directing group was utilized for the regioselective γ−C(alkenyl)−H functionalization of unactivated alkenes with vinylcyclopropanes. This protocol exhibits wide substrate scope and good selectivity. Additionally, substrate diversification was performed to demonstrate the synthetic utility of the protocol. Mechanistic investigations were carried out to provide an insight to the reaction mechanism. A plausible mechanism was also proposed for the present methodology.