Palladium-Catalyzed Aminations in Flow ... on Water

Abstract

Aminations can be efficiently run, under plug flow conditions on water, catalyzed by low levels of a recyclable palladium precatalyst. General protocols to couple amines, both aryl and aliphatic, with aryl/heteroaryl bromides have been developed. Further highlights include "on water" conditions, short reaction times, recycling of the reaction medium, low levels of residual Pd in the isolated products, and low E factors as a green metric, all of these features showcasing this alternative to amination reactions typically run in batch mode.

Ligated Pd-Catalyzed Aminations of Aryl/Heteroaryl Halides with Aliphatic Amines under Sustainable Aqueous Micellar Conditions

“…Furthermore, aminations via continuous flow have also been carried out successfully not only using aliphatic amines but also with aromatic amines on aromatic/heteroaromatic halides …”