Palladium-Catalyzed Arylation of Aromatic Amides Directed by a [4-Chloro-2-(1H-pyrazol-1-yl)phenyl]amine Auxiliary

Abstract

A palladium-catalyzed ortho-arylation of aromatic amides ­directed by [4-chloro-2-(1H-pyrazol-1-yl)phenyl]amine as a bidentate auxiliary has been established. The reaction is characterized by normal working conditions, a broad substrate scope, and a wide functional-group tolerance. In particular, the protocol is compatible with highly sterically demanding ortho-substituted anilides and aryl iodide partners, with good yields.

Ruthenium(II)-Catalyzed α-Fluoroalkenylation of Oxime Ethers with gem-Difluorostyrenes via C–H Activation and C–F Cleavage

“…In particular, the ortho -methoxy-substituted oxime ether gave a reduced yield of 56% ( 3n ). It is possibly because of potentially strong chelation of the methoxy with the catalyst, leading to the blocked catalytic cycle . Furthermore, the fused-cyclic substrates were also reacted smoothly to produce 3q–3r in lower yields albeit with prolonged reaction time.…”