Palladium‐Catalyzed C‐H Olefination of Imidazo[1,2a] pyridine Carboxamide in Aqueous Ethanol under Oxygen

Abstract

The advancement of sustainable chemistry and changes in the economy are strongly intertwined. Reaction time, cost savings, moderate temperatures, and generation of the fewest byproducts are frequently achieved by using catalytic processes. Herein, we report the C‐H olefination of imidazo[1,2a] pyridine carboxamides with various acrylates in the presence of Pd(OAc)2 with O2 as the oxidant in aqueous ethanol rather than using non‐ecofriendly solvents. The C‐H activation features most user‐friendly reaction conditions, excellent yield as well as plenty substrate scope and applicable for C‐H deuteriation of the corresponding heteroarenes with D2O. Experimental mechanistic studies indicate that C‐H activation step succeeded after formation of tetra coordinated square planer Pd‐substrate adduct.