Palladium‐Catalyzed C8‐Fluoroalkylation and C8‐Fluoroalkenylation of Naphthalenes by C−H Activation

Abstract

In this study, two novel C8‐functionalization methods of 1‐carbonylnaphthalenes are detailed. Leveraging iodonium triflate as coupling partners, we disclosed palladium‐catalyzed C8‐fluoroalkylation and C8‐fluoroalkenylation processes. These protocols exhibit broad applicability across diverse naphthalene derivatives, thanks to carbonyl directing groups at C1 position which can be retained for subsequent applications or selectively removed, enhancing the versatility of the developed methodologies.