Palladium-catalyzed coupling reactions in flavonoids: A retrospective of recent synthetic approaches

Design and Discovery of Water-Soluble Benzooxaphosphole-Based Ligands for Hindered Suzuki–Miyaura Coupling Reactions with Low Catalyst Load

“…Palladium-catalyzed Suzuki–Miyaura cross-coupling reactions have advanced into one of the most powerful carbon–carbon bond-forming reactions. − It is one of the catalytic C–C forming transformations that has been applied successfully on commercial scales for synthesizing key intermediates and active ingredients in the pharmaceutical , and agricultural arena . As a result, the Suzuki–Miyaura reaction has garnered immense interest in the synthetic research community to continue investing on identifying sustainable conditions with new and effective catalysts and in alternative solvent systems. − The first water-soluble ligand for this reaction was developed from the sulfonation of a monodentate phosphine ligand and has been applied in Pd-catalyzed Suzuki–Miyaura reactions in aqueous media, albeit with a higher catalyst load than in its organic solvent counterpart. − Recently, Buchwald and co-workers developed new water-soluble ligands, which have addressed the greenness and sustainability of the Suzuki–Miyaura coupling reactions.…”