Palladium‐Catalyzed Dehydrogenative Cross‐Couplings of Benzazoles with Azoles

Dual C–H activations of electron-deficient heteroarenes: palladium-catalyzed oxidative cross coupling of thiazoles with azine N-oxides

“…Ofial has reported the Pd(II)-catalyzed cross-coupling of benzazoles with azoles. 15 Later on, You and co-workers developed the oxidative crosscoupling between two structurally similar azoles. 16 Very recently, Cu(OAc) 2 -mediated dehydrogenative cross-coupling between two heteroarenes has been realized.…”

Cobalt-Promoted Dimerization of Aminoquinoline Benzamides

“…2 Cross-coupling of heterocycles and acidic arenes with each other or simple benzene derivatives is also possible. 3 In rare cases when simple arenes such as toluene are coupled, isomer mixtures of products are usually obtained. 4 Furthermore, reactions often require either palladium or rhodium catalysts or several equivalents of silver salt additives.…”

“…Furthermore, very few reports describe dehydrogenative arene couplings that do not require second-row transition metals as catalysts or additives. 2f,3d,e,9g …”

Biaryl Synthesis through Metal‐Catalyzed C–H Arylation

“…In the same year, Ofial [226] discovered an efficient C-H/C-H cross-coupling reaction between very similar partners such as different azoles. For example, treatment of benzothiazole with a slightly excess of N-methylimidazole under the influence of catalytic Pd(OAc) 2 and stoichiometric Cu(OAc) 2 ·H 2 O, KF, and AgNO 3 delivered the corresponding cross-coupling product 172 in excellent yield and selectivity.…”