Palladium‐catalyzed difluoromethylation and difluoroalkylation reactions: An overview

Abstract

Broad functional group compatibility and gentle reaction conditions are the advantages of the majority of the palladium‐catalyzed reactions. Fascinating pharmacokinetic properties are possessed by the difluoromethyl group that is isopolar and isosteric to hydroxyl group. The difluoromethylene group is bioisostere for a carbonyl group or an oxygen atom. These groups are present in the structures of plenty of agrochemicals and drug molecules. Attempts to develop new approaches for difluoromethylation and difluoroalkylation reactions are growing notably. Owing to the importance of these compounds in diverse fields, the advances and prospects of palladium‐catalyzed difluoromethylation and difluoroalkylation reactions are reviewed here covering literature up to 2021.