Palladium-Catalyzed E-Selective Oxidative Amination of Aromatic Amine with 3-Butenoic Acid

Abstract

A palladium-catalyzed oxidative amination of inactive olefins with an aromatic amine was developed using a copper acetate oxidant to yield corresponding secondary and tertiary enamines in moderate to good yields. This new procedure outlines an efficient approach for the construction of enamine skeletons.Article pubs.acs.org/joc

Palladium Catalysis: Dependence of the Efficiency of C–N Bond Formation on Carboxylate Ligand and Metal Carboxylate or Carboxylic Acid Additive

“…Recently, Huang, Zhao, and co-workers 9 disclosed the synthesis of amino acid 2d1 from the Pd II -catalyzed addition of N -methylaniline to 3 - butenoic acid ( Scheme 2 d). Preliminary experiments were performed in toluene with Cu II salts and additives, alkali acetates, or carboxylic acids under air.…”