“…In 2013, Shipman and co-workers reported an efficient three-component reaction to synthesize 2aryl-2-imidazolines, in a palladium mediated catalytic cycle (70) (Scheme 20). [41] The reaction combines aryl halides (67), isocyanides (68), and diamines (69). Initially, different palladium catalysts and ligands were screened with ethylenediamine, tert-butyl isocyanide ( t BuNC), and phenyl iodide (PhI) and the authors identified two combinations of catalyst and ligand, as the most suitable for this reaction.…”