Palladium‐Catalyzed Selective 2,3‐Diarylation of α,α‐Disubstituted 3‐Thiophenemethanols via Cleavage of C—H and C—C Bonds.

Abstract

Thiophene derivatives R 0090 Palladium-Catalyzed Selective 2,3-Diarylation of α,α-Disubstituted 3-Thiophenemethanols via Cleavage of C-H and C-C Bonds. -In the presence of Pd(O-Ac) 2 and a bulky phosphine, 3-thiophenemethanols of type (I) and their benzothiophene analogues undergo selective diarylation. -(NAKANO, M.; SATOH, T.; MIURA*, M.; J. Org. Chem. 71 (2006) 21, 8309-8311; Dep. Appl. Chem., Fac. Eng.