Palladium‐Catalyzed Tandem Allylation of 1,2‐Phenylenediamines with cis‐1,4‐Diacetoxy‐2‐butene.

Abstract

Pyrazine derivatives Pyrazine derivatives R 0550Palladium-Catalyzed Tandem Allylation of 1,2-Phenylenediamines with cis-1,4-Diacetoxy-2-butene. -Pd-catalyzed cyclization of phenylenediamine (Ia) with cis-1,4-diacetoxy-2-butene (II) is optimized. The best yields are obtained under conditions A). -(YANG*, S.-C.; LIU, P.-C.; FENG, W.-H.; Tetrahedron Lett. 45 (2004) 25, 4951-4954; Grad. Inst. Pharm. Sci., Kaohsiung Med. Coll., Kaohsiung 80708, Taiwan; Eng.) -Roy 39-143