Palladium Complexes of N,N′-Bis(2-aminoethyl)oxamide (H2L): Structural (PdIIL, PdII2L2, and PdIVLCl2), Electrochemical, Dynamic 1H NMR, and Cytotoxicity Studies

Gavrish, Sergey P.; Lampeka, Ya. D.; Babak, Maria V.; Arion, Vladimir B.

doi:10.1021/acs.inorgchem.7b02732

Cited by 13 publications

(3 citation statements)

References 44 publications

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“…On the other hand, oxamide-based ligands such as N,N ′ -bis(substituted) oxamide have ourished indeed since they can be used to construct complexes with structural diversity. [28][29][30][31] In addition to the utilization of an oxamide-based ligand, the incorporation of 1,10-phennanthroline as a secondary ligand was deemed necessary due to the fact that 1,10-phennanthroline derivatives have demonstrated noteworthy biological activity, including but not limited to antibacterial, antifungal, and antiviral properties. 32 These complexes have shown promising results in improving the antitumor activity.…”

Section: Introductionmentioning

confidence: 99%

A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity

Cao,

Wang,

et al. 2023

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity

Cao,

Wang,

et al. 2023

RSC Adv.

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“…However, their dosage is restrained due to their unsympathetic side effects such as nausea, vomiting, loss of sensation in the extremities, and nephrotoxicity. , Pd(II) complexes are noteworthy alternatives for the treatment of cancer because of their structural and thermodynamic similarities to Pt(II) complexes. − There have been numerous reports on Pd(II) complexes with potential anticancer properties against various cancer cell lines (lung, prostate, etc. ); some are showing better activity (predominantly in in vitro system) than their Pt(II) counterparts. − Pd(II) complexes have shown remarkable antiproliferative effects on human breast cancer including tumor cell lines that are resistant to cisplatin, and also displayed good antimycobacterial effects. − …”

Section: Introductionmentioning

confidence: 99%

Synthesis of Palladium(II) Complexes via Michael Addition: Antiproliferative Effects through ROS-Mediated Mitochondrial Apoptosis and Docking with SARS-CoV-2

et al. 2020

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Metal complexes have numerous applications in the current era, particularly in the field of pharmaceutical chemistry and catalysis. A novel synthetic approach for the same is always a beneficial addition to the literature. Henceforth, for the first time, we report the formation of three new Pd(II) complexes through the Michael addition pathway. Three chromone-based thiosemicarbazone ligands (SVSL1–SVSL3) and Pd(II) complexes ( 1 – 3 ) were synthesized and characterized by analytical and spectroscopic tools. The Michael addition pathway for the formation of complexes was confirmed by spectroscopic studies. Distorted square planar structure of complex 2 was confirmed by single-crystal X-ray diffraction. Complexes 1 – 3 were subjected to DNA- and BSA-binding studies. The complex with cyclohexyl substituent on the terminal N of thiosemicarbazone ( 3 ) showed the highest binding efficacy toward these biomolecules, which was further understood through molecular docking studies. The anticancer potential of these complexes was studied preliminarily by using MTT assay in cancer and normal cell lines along with the benchmark drugs (cisplatin, carboplatin, and gemcitabine). It was found that complex 3 was highly toxic toward MDA-MB-231 and AsPC-1 cancer cells with IC 50 values of 0.5 and 0.9 μM, respectively, and was more efficient than the standard drugs. The programmed cell death mechanism of the complexes in MDA-MB-231 cancer cells was confirmed. Furthermore, the complexes induced apoptosis via ROS-mediated mitochondrial signaling pathway. Conveniently, all the complexes showed less toxicity (≥50 μM) against MCF-10a normal cell line. Molecular docking studies were performed with VEGFR2, EGFR, and SARS-CoV-2 main protease to illustrate the binding efficiency of the complexes with these receptors. To our surprise, binding potential of the complexes with SARS-CoV-2 main protease was higher than that with chloroquine and hydroxychloroquine.

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“…The so-called ATCUN-motif (Amino Terminal Cu and Ni) forms strong coordinating ligands with histidine as the third amino residue for the N-terminus (as seen in Figure 1 a). Innumerable possibilities of side chain combinations and modifications allow a variety of metal complexes to be synthesized with tunable geometries and electronic properties [ 8 , 10 , 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Reaction Studies of Pd(II) Tripeptide Complexes

et al. 2021

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The aqueous synthesis of Pd(II) complexes with alkylated tripeptides led to the hydrolysis of the peptides at low pH values and mixtures of complexed peptides were formed. A non-aqueous synthetic route allowed the formation and isolation of single products and their characterization. Pd(II) complexes with α-Asp(OR)AlaGly(OR), β-Asp(OR)AlaGly(OR), and TrpAlaGly(OR) (R = H or alkyl) as tri and tetradentate chelates were characterized. The tridentate coordination mode was accompanied by a fourth monodentate ligand that was shown to participate in both ligand exchange reactions and a direct removal to form the tetradentate coordination mode. The tetradentate coordination revealed a rare a hemi labile carbonyl goup coordination mode to Pd(II). Reactivity with small molecules such as ethylene, acids, formate, and episulfide was investigated. Under acidic conditions and in the presence of ethylene; acetaldehyde was formed. The Pd(II) is a soft Lewis acid and thiophilic and the complexes abstract sulfur from episulfide at apparent modest catalytic rates. The complexes adopt a square planar geometry according to a spectroscopic analysis and DFT calculations that were employed to evaluate the most energetically favorable coordination geometry and compared with the observed infrared and NMR data.

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Palladium Complexes of N,N′-Bis(2-aminoethyl)oxamide (H₂L): Structural (Pd^IIL, Pd^II₂L₂, and Pd^IVLCl₂), Electrochemical, Dynamic ¹H NMR, and Cytotoxicity Studies

Cited by 13 publications

References 44 publications

A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity

A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity

Synthesis of Palladium(II) Complexes via Michael Addition: Antiproliferative Effects through ROS-Mediated Mitochondrial Apoptosis and Docking with SARS-CoV-2

Synthesis, Characterization, and Reaction Studies of Pd(II) Tripeptide Complexes

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