Palladium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones: spectral characterization, structural studies and cytotoxic activity

On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas

“…Thus the metal is coordinated to the negatively charged organic molecules, which act as bidentate ligands, through oxygen (average distance Pd\O = 2.059 Å) and sulfur (average distance Pd\S = 2.2924 Å) atoms. The Pd\S average distance is close to the ones found for other palladium(II) thiosemicarbazones complexes [36]. The remaining binding sites are occupied by triphenylphosphines (average distance Pd-P1 = 2.2577 Å and Pd-P2 = 2.3455 Å), or by the chloride in the case of complex (1), where the distance Pd-Cl is 2.3269(9) Ả, which is close to those reported in the literature [36].…”

“…The Pd\S average distance is close to the ones found for other palladium(II) thiosemicarbazones complexes [36]. The remaining binding sites are occupied by triphenylphosphines (average distance Pd-P1 = 2.2577 Å and Pd-P2 = 2.3455 Å), or by the chloride in the case of complex (1), where the distance Pd-Cl is 2.3269(9) Ả, which is close to those reported in the literature [36]. The distances for the C\S, C\N and C\O bonds in the chelate rings, listed in Table 2, are the characteristic of single and double bond lengths, respectively [44].…”

“…The absorptions at 815-878 cm −1 in the spectra of free bases, N,N-disubstituted-N′-acyl thioureas, attributed to the ν(C_S) stretching vibrations, shift to the 752-799 cm −1 range in the complexes spectra. This substantial change suggests deprotonation of the ligands, indicating coordination through the sulfur atom with a formally C\S single bond [34][35][36][37]. The absorptions at about 470 cm − 1 in the IR spectra of the complexes can be assigned to the M\O vibration mode [38,39] and the assignment of the Pd\S stretching vibration bands at about 330 cm −1 are in accordance to the reported by Orysyk et al for palladium(II) complexes with 1-allyl-3-(2-pyridyl)thioureas [40].…”

Structural Studies and Investigation on the Activity of Imidazole-Derived Thiosemicarbazones and Hydrazones against Crop-Related Fungi

“…Thiosemicarbazones and hydrazones were prepared according to procedures previously employed by our group [15,19,[31][32][33]. Melting points were determined using the digital Mettler Toledo FP90 equipment.…”

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

“…Cytostatic activity against CEM (human T-lymphocytes) and HeLa (human cervix carcinoma) cell lines were measured essentially as originally described for the mouse leukemia cell lines [8]. Human lymphocyte CEM and human cervix carcinoma HeLa cells were seeded in 96-well microtiter plates at 75,000 (CEM) or 20,000 (HeLa) cells per 200 mL-well in the presence of different concentrations of the test compounds.…”