Palladium(II) imine ligands cyclometallated complexes with a potential leishmanicidal activity on Leishmania (L.) amazonensis

Nickel Complexes Bearing N,N,O-Tridentate Salicylaldiminato Ligand: Efficient Catalysts for Imines Formation via Dehydrogenative Coupling of Primary Alcohols with Amines

“…Since diimine compounds are usually used as important organic ligands to support various metals in catalytic chemistry and showed good bioactivity in medicine, , we then extended our present catalytic system for coupling diamines with benzyl alcohols to access diimine products (Table ). Benzene-1,3-diamine and benzene-1,4-diamine reacted smoothly with benzyl alcohol 5a and gave the corresponding diimine 10a and 10b in >70% yields.…”

Metal Compounds against Neglected Tropical Diseases

“…In vivo testing showed that, when compared to that in the controls, the antileishmanial activity was significantly higher in treated Wistar rats where the parasites were reduced by 88 ± 2.6%, and in the spleen, amastigotes were reduced to 50% per gram of spleen. 239 reported that three Pd(II) cyclometalated complexes derived from imines were more bioactive against both L. donovani promastigotes and amastigotes (IC 50 = 100 mg/mL) and less cytotoxic than the pentamidine control. 238 The coordination of the imine to the metal complex further increased the bioactivity of the complex without increasing the cytotoxicity, indicating that the metal ion has a role in the selectivity of the complex toward Leishmania.…”

Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases

“…The final set of antiprotozoal compounds are also in relation to leishmaniasis and significantly differ in chemistry from the previous cases, encompassing all their organometallic character in a single carbon-palladium bond. The group of Franco et al 51 have utilized two types of imine ligands, cyclometalating them with palladium to give the proposed structures 15a-16 (Fig. 12).…”

“…59 Despite these limitations, praziquantel has proved generally successful and the main purpose of Fig. 12 Proposed structures of cyclometalated organopalladiumIJII) complexes synthesised by Franco et al 51 with activity (IC 50 ) against amastigote form of L. donovani and selectivity over mammalian cells (selectivity index, SI). The activity and selectivity of the free ligands and reference drug, pentamidine, are also given.…”