Re: Palliative bypass for small bowel carcinoid with mesenteric mass and vascular encasementWe read with interest the recent publication by Nathan et al. 1 that intestinal bypass should be considered as a palliative measure for patients with unresectable small bowel neuroendocrine tumours. As the authors correctly state, symptoms are often related to the ischaemia, which is the result of the desmoplastic response to the mesenteric nodal disease, and therefore, symptoms persist following intestinal bypass. However, the authors have incorrectly quoted Boudreux et al. 2 who discuss symptom improvement and increased survival following resection of the small bowel and nodal disease in the presence of distant metastatic disease, not residual mesenteric nodal disease. We are not aware of any published studies reporting improved quality of life for small bowel neuroendocrine tumours treated with intestinal bypass. Nathan et al. do not mention if there was improvement in the post-operative symptoms for the reported patient. If discovered at emergency laparotomy, intestinal bypass may be the only possible treatment for obstruction. In our experience, however, this rarely leads to resolution of symptoms because of the persistent ischaemia from the mesenteric nodal disease and worsening of diarrhoea. In an elective setting or subacute bowel obstruction, we would suggest preoperative staging with 68 Ga-DOTATATE PET CT 3 as well as computed tomography of the mesenteric vasculature to avoid surgery in those with metastatic disease or unresectable nodal disease. Symptomatic relief may also be possible with long-acting somatostatin analogues or peptide receptor radionuclide treatment 4 without surgery. To avoid surgical bypass, consideration of referral to a service experienced in the management of resection of neuroendocrine nodal disease should be considered.