Palliative effect of Moringa olifera-mediated zinc oxide nanoparticles against acrylamide-induced neurotoxicity in rats

Dahran, Naief; Abd‐Elhakim, Yasmina M.; Mohamed, Amany Abdel-Rahman; Abd-Elsalam, Marwa M.; Said, Enas N.; Metwally, Mohamed M.M.; Abdelhamid, Ahmed E.; Hassan, Bayan A.; Alsieni, Mohammed; Alosaimi, Manal E.; Abduljabbar, Maram H.; El‐Shetry, Eman S.

doi:10.1016/j.fct.2022.113537

Cited by 22 publications

(12 citation statements)

References 128 publications

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“…After washing the slices three times with PBS for 5 min each, the secondary antibody was added and the slices were incubated at 37 °C for 30 min. Diaminobenzidine was used for color rendering for 5–10 min, followed by hematoxylin staining for 3 min [ 19 ]. The slices were observed under a microscope, and the integrated optical density (IOD) was measured using Image Pro Plus 6.0 image software.…”

Section: Methodsmentioning

confidence: 99%

Multi-omics landscape analysis reveals the pan-cancer association of arginine biosynthesis genes with tumor immune evasion and therapy resistance

Tan,

Li,

Huang

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

Multi-omics landscape analysis reveals the pan-cancer association of arginine biosynthesis genes with tumor immune evasion and therapy resistance

Tan,

Li,

Huang

et al. 2024

Heliyon

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“…Nano‐formulation that generates a supramolecular complex with the ion by reversible binding may diffuse through hydrophobic membranes 18 . Therefore, Zn supplementation has been shown to have potent anti‐diabetic activity, has alleviated the progression of neurodegeneration, and seems to ameliorate glycemic control in both diabetes types by protecting pancreatic β cells from being destroyed by immune cells and cytokines 19 . Luteolin, also known as 3′, 4′, 5, 7‐tetrahydroxyflavone, is a flavonoid found in a variety of plants such as fruits, veggies, and herbal remedies.…”

Section: Introductionmentioning

confidence: 99%

“…18 Therefore, Zn supplementation has been shown to have potent anti-diabetic activity, has alleviated the progression of neurodegeneration, and seems to ameliorate glycemic control in both diabetes types by protecting pancreatic β cells from being destroyed by immune cells and cytokines. 19 Luteolin, also known as 3 0 , 4 0 , 5, 7-tetrahydroxyflavone, is a flavonoid found in a variety of plants such as fruits, veggies, and herbal remedies. Luteolin has been shown to have a variety of therapeutic capabilities, notably antioxidant and anti-inflammatory properties.…”

mentioning

confidence: 99%

Luteolin/ZnO nanoparticles attenuate neuroinflammation associated with diabetes via regulating MicroRNA‐124 by targeting C/EBPA

Moustafa

Moawed

El-Maghraby

2023

Environmental Toxicology

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ObjectiveThe most prevalent brain‐specific microRNA, MicroRNA‐124, exhibits anti‐inflammatory properties. Luteolin nano‐formulation with Zn oxide in the form of L/ZnO NPs may boost anti‐diabetic properties; however, its beneficial effect on miRNAs is yet unknown in diabetes. The effectiveness of L/ZnONPs supplements in preventing diabetic neurodegeneration by modulating inflammatory responses in a diabetic model was investigated.MethodsA diabetic rat model was induced by a high‐fat diet and streptozotocin (30 mg/kg I.P.). Plasma glucose, insulin, and HOMR‐IR levels, as well as cytokines, lipid peroxidation, GSH/GSSG, and glucose transporter 1, were determined along with the tight junction proteins occludin (OCLN) and zona occludens 1 (ZO‐1). Moreover, the expressions of brain CCAAT/enhancer‐binding protein (C/EBPA mRNA), miR‐124, glial fibrillary acidic protein (GFAP), and NF‐kBp65 were measured alongside the histological investigation.ResultsThe results revealed that L/ZnO NPs were able to diminish lipid peroxidation, increase the activity of antioxidant enzymes, and reduce inflammation under oxidative stress. Consequently, it was able to reduce hyperglycemia, elevate insulin levels, and improve insulin resistance. Besides, L/ZnO NPs upregulate miR‐124, reduce C/EBPA mRNA, increase BCl‐2, and inhibit apoptosis. The results indicate that diabetes raises BBB permeability via tight junction protein decline, which is restored following L/ZnO NPs treatment. Luteolin/ZnO NPs regulate miR‐124 and microglia polarization by targeting C/EBPA and are expected to alleviate inflammatory injury via modulation of the redox‐sensitive signal transduction pathways. Luteolin/ZnO NPs have a novel target for the protection of the BBB and the prevention of neurological complications in diabetes.

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“…With the progress of nanotechnology, innovative novel nanoparticles (NPs) have been developed and have found success in a wide range of applications in different fields (Abd El-Hakim et al 2020 ; Selim et al 2015 ; Vance et al 2015 ). Zinc oxide nanoparticles (ZNPs) are one of the most developed and useful nanomaterials in modern manufacturing processes (Dahran et al 2023 ; Mahfouz et al 2023 ).…”

Section: Introductionmentioning

confidence: 99%

“…Therapeutic interventions have been sought for decades to stop the worsening of neurobehavioral disorders and brain injuries or speed their recovery (Abd-Elhakim et al 2021 , 2020 ; Behairy et al 2020 ; Dahran et al 2023 ). Toxins from venomous organisms such as spiders, snakes, scorpions, bees, toads, ants, wasps, and frogs have shown great promise for pharmaceutical uses (de Souza et al 2018b ).…”

Section: Introductionmentioning

confidence: 99%

Bee venom (Apis mellifera L.) rescues zinc oxide nanoparticles induced neurobehavioral and neurotoxic impact via controlling neurofilament and GAP-43 in rat brain

Eleiwa

Ali

Said

et al. 2023

Environ Sci Pollut Res

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This study investigated the possible beneficial role of the bee venom (BV, Apis mellifera L.) against zinc oxide nanoparticles (ZNPs)-induced neurobehavioral and neurotoxic impacts in rats. Fifty male Sprague Dawley rats were alienated into five groups. Three groups were intraperitoneally injected distilled water (C 28D group), ZNPs (100 mg/kg b.wt) (ZNPs group), or ZNPs (100 mg/kg.wt) and BV (1 mg/ kg.bwt) (ZNPs + BV group) for 28 days. One group was intraperitoneally injected with 1 mL of distilled water for 56 days (C 56D group). The last group was intraperitoneally injected with ZNPs for 28 days, then BV for another 28 days at the same earlier doses and duration (ZNPs/BV group). Depression, anxiety, locomotor activity, spatial learning, and memory were evaluated using the forced swimming test, elevated plus maze, open field test, and Morris water maze test, respectively. The brain contents of dopamine, serotonin, total antioxidant capacity (TAC), malondialdehyde (MDA), and Zn were estimated. The histopathological changes and immunoexpressions of neurofilament and GAP-43 protein in the brain tissues were followed. The results displayed that BV significantly decreased the ZNPs-induced depression, anxiety, memory impairment, and spatial learning disorders. Moreover, the ZNPs-induced increment in serotonin and dopamine levels and Zn content was significantly suppressed by BV. Besides, BV significantly restored the depleted TAC but minimized the augmented MDA brain content associated with ZNPs exposure. Likewise, the neurodegenerative changes induced by ZNPs were significantly abolished by BV. Also, the increased neurofilament and GAP-43 immunoexpression due to ZNPs exposure were alleviated with BV. Of note, BV achieved better results in the ZNPs + BV group than in the ZNPs/BV group. Conclusively, these results demonstrated that BV could be employed as a biologically effective therapy to mitigate the neurotoxic and neurobehavioral effects of ZNPs, particularly when used during ZNPs exposure.

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Palliative effect of Moringa olifera-mediated zinc oxide nanoparticles against acrylamide-induced neurotoxicity in rats

Cited by 22 publications

References 128 publications

Multi-omics landscape analysis reveals the pan-cancer association of arginine biosynthesis genes with tumor immune evasion and therapy resistance

Multi-omics landscape analysis reveals the pan-cancer association of arginine biosynthesis genes with tumor immune evasion and therapy resistance

Luteolin/ZnO nanoparticles attenuate neuroinflammation associated with diabetes via regulating MicroRNA‐124 by targeting C/EBPA

Bee venom (Apis mellifera L.) rescues zinc oxide nanoparticles induced neurobehavioral and neurotoxic impact via controlling neurofilament and GAP-43 in rat brain

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