Palliative systemic therapy for young women with metastatic breast cancer

Eng, Lee Guek; Dawood, Shaheenah; Dent, Rebecca

doi:10.1097/spc.0000000000000163

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…There is a higher proportion of TNBC and HER2+ disease in young women with metastatic breast cancer [ 344 , 345 ]. The first-line treatment is chemotherapy, with or without targeted therapy.…”

Section: Treatmentmentioning

confidence: 99%

What Is Known about Breast Cancer in Young Women?

Zhu

Charkhchi

Adekunte

et al. 2023

Cancers

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Breast cancer (BC) is the second leading cause of cancer-related death in women under the age of 40 years worldwide. In addition, the incidence of breast cancer in young women (BCYW) has been rising. Young women are not the focus of screening programs and BC in younger women tends to be diagnosed in more advanced stages. Such patients have worse clinical outcomes and treatment complications compared to older patients. BCYW has been associated with distinct tumour biology that confers a worse prognosis, including poor tumour differentiation, increased Ki-67 expression, and more hormone-receptor negative tumours compared to women >50 years of age. Pathogenic variants in cancer predisposition genes such as BRCA1/2 are more common in early-onset BC compared to late-onset BC. Despite all these differences, BCYW remains poorly understood with a gap in research regarding the risk factors, diagnosis, prognosis, and treatment. Age-specific clinical characteristics or outcomes data for young women are lacking, and most of the standard treatments used in this subpopulation currently are derived from older patients. More age-specific clinical data and treatment options are required. In this review, we discuss the epidemiology, clinicopathologic characteristics, outcomes, treatments, and special considerations of breast cancer in young women. We also underline future directions and highlight areas that require more attention in future studies.

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Section: Treatmentmentioning

confidence: 99%

What Is Known about Breast Cancer in Young Women?

Zhu

Charkhchi

Adekunte

et al. 2023

Cancers

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“…Chemotherapy only increases the 15-year survival rate of women under 50 by 10%; in elderly women this increase is only 3% [15,16]. No technology currently exists for the accurate prediction of metastasis; consequently, patients are subject to the toxic side effects of classic chemotherapy, which substantially affect the patients' quality of life [17][18][19]. Therefore, there is an urgent need to necessitate concerted efforts to identify effective agents against TNBC.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Beebe¹,

Celestine

Bullock

et al. 2020

Journal of Inorganic Biochemistry

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× 10 5 and 1.6 × 10 4 M −1 , respectively). Topoisomerase inhibition assays and cleavage studies proved that complex 4 was an efficient catalytic inhibitor of human topoisomerases I and IIα. Based upon the results obtained from the 3-(4,5-dimethylthiazol-2-yl)-5-(3carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay on 4T1-luc metastatic mammary breast cancer cells (IC 50 = 34.4 ± 5.2 μM when compared to IC 50 = 13.75 ± 1.08 μM for the control, cisplatin), further investigations into the molecular events initiated by exposure to complex 4 were investigated. Studies have shown that complex 4 activated both the apoptotic and autophagic signaling pathways in addition to causing dissipation of the mitochondrial membrane potential (ΔΨ m). Furthermore, activation of cysteine-aspartic proteases3 (caspase 3) in a time-and concentration-dependent manner coupled with the ΔΨ m , studies implicated the intrinsic apoptotic pathway as the major regulator of cell death mechanism.

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“…Palliative care, defined as an approach that improves the QoL of patients and families facing life-threatening disease through prevention or early identification and treatment, is a key intervention for women living with breast cancer. [ 12 ] Religiosity is an essential component of palliative care that has attracted increasing interest in recent years among cancer patients, especially those with breast cancer. [ 13 14 ] Religiosity is an expression of spirituality and is defined as a set of beliefs and practices associated with a particular religious tradition or denomination.…”

Section: Introductionmentioning

confidence: 99%

A Survey on the Relationship between Religiosity and Quality of Life in Patients with Breast Cancer: A Study in Iranian Muslims

Zargani

Nasiri

Hekmat

et al. 2018

Asia-Pacific Journal of Oncology Nursing

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Objective:This study aimed to assess the relationship between religiosity and quality of life (QoL) in patients with breast cancer in a Muslim population.Methods:This descriptive-correlational study was conducted in 84 Muslim patients with breast cancer who were admitted to Ahvaz Shafa Hospital, Iran, during 2015. QoL and religiosity were measured with the Short Form-36 questionnaire and Muslim Religiosity questionnaire based on the Glock and Stark model, respectively. Data were analyzed using a software program for descriptive statistics, the Chi-square test, Pearson's correlation, and an independent sample t-test.Results:Most patients had high religiosity (69%) and moderate QoL (46.5%) scores. Total scores and all subscales scores for QoL were significantly higher in patients with high religiosity than patients with moderate religiosity (P < 0.0001). Moreover, a direct correlation was found between religiosity (total and all subscales) and QoL (total and all subscales) (P < 0.0001).Conclusions:A significant relationship was found between religiosity and QoL in patients with breast cancer. Accordingly, care team members, especially midwifery and nursing staff, should pay more attention to religious beliefs among these patients to improve their QoL.

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Palliative systemic therapy for young women with metastatic breast cancer

Abstract: Combined palliative and holistic approaches are essential to help young women navigate the marathon of treatment for metastatic breast cancer.

Cited by 6 publications

References 54 publications

What Is Known about Breast Cancer in Young Women?

What Is Known about Breast Cancer in Young Women?

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

A Survey on the Relationship between Religiosity and Quality of Life in Patients with Breast Cancer: A Study in Iranian Muslims

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