Palmar‐Plantar Keratoderma of Unna Thost Associated with Atopic Dermatitis: An Underrecognized Entity?

Abstract

We report six cases of palmar-plantar keratoderma of Unna Thost (PPKUT) associated with atopic dermatitis. All had typical features of PPKUT with diffuse, yellowish thickening on the palms and soles with a well-defined erythematous rim of demarcation on the sides associated with palmar-plantar hyperhidrosis. The changes were obvious since birth or arose during early life, and were persistent. We believe that the association between the two disorders is not coincidental but an underrecognized entity that may shed light on the underlying pathogenesis of these two conditions.

A rare case of lichen planus pemphigoides with palmoplantar hyperkeratotic plaques

“…To our knowledge, 4 cases have been published in the medical literature detailing cases of LPP presenting with palmoplantar keratoderma (PPK). 6 , 7 , 8 , 9 , 10 One of these patients had a history of hereditary Unna-Thost PPK since childhood, 7 however, the 3 other cases presented with hyperkeratotic plaques on palmar and plantar surfaces in temporal association with the onset of LPP symptoms, 6 , 8 , 9 which was the case in our patient’s clinical presentation. Further, biopsy of plantar lesions in 1 case confirmed typical lichen planus features on histology.…”

Topical Selenium Sulfide for the Treatment of Hyperkeratosis

“…All of our patients had plantar hyperkeratosis. One man had congenital hyperkeratosis of the palms and soles consistent with Unna–Thost disease [ 19 , 20 ]. The other patients both had lower extremity edema and acquired hyperkeratosis; the woman had spina bifida and hyperkeratosis of her plantar feet whereas the man’s hyperkeratosis was idiopathic and he had hyperkeratosis of his hands, feet, and distal legs.…”