Palmatine Attenuates Metastatic Lung Colonization of Triple Negative Breast Cancer Cells

Ativui, Selase; Danquah, Cynthia Amaning; Ossei, Paul Poku Sampene; Ofori, Michael

doi:10.3389/fphar.2022.853230

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…[50] At the same time, palmatine can inhibit lung metastasis of adenocarcinoma cells and prevent lung structural changes, which is achieved by upregulating the expression of tumor suppressor p53 and thus inhibiting the transcription of metastasis-associated protein 1. [51]…”

Section: Discussionmentioning

confidence: 99%

Reverse predictive analysis of Rhizoma Pinelliae and Rhizoma Coptidis on differential miRNA target genes in lung adenocarcinoma

et al. 2023

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To use bioinformatics and network analysis to reveal the mechanism of "Rhizoma Pinelliae-Rhizoma Coptidis" herb pair in the treatment of lung adenocarcinoma. The target and pathway of "Rhizoma Pinelliae-Rhizoma Coptidis" herb pair in the treatment of lung adenocarcinoma were explored by online databases and network analysis tools, and the potential biomarkers of "Rhizoma Pinelliae-Rhizoma Coptidis" herb pair in the treatment of lung adenocarcinoma were predicted in reverse. A total of 59 traditional Chinese medicine compounds and 510 drug targets were screened in this study. A total of 25 micro-RNAs and 15,323 disease targets were obtained through GEO2R software analysis. In the end, 294 therapeutic targets and 47 core targets were obtained. A total of 186 gene ontology enrichment assays were obtained, and core therapeutic targets play multiple roles in biological processes, molecular functions, and cellular composition. Kyoto encyclopedia of genes and genomes pathway enrichment analysis showed that the core targets were mainly enriched in cancer-related pathways, immune-related pathways, endocrinerelated pathways, etc, among which the non-small cell lung cancer pathway was the most significant core pathway. Molecular docking shows that the compound and the target have good binding ability. "Rhizoma Pinelliae-Rhizoma Coptidis" herb pair plays a mechanism of action in the treatment of lung adenocarcinoma through multiple targets and pathways. miR-5703, miR-3125, miR-652-5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.Abbreviations: EGFR = epidermal growth factor receptor, FoxO = forkhead box O, GO = gene ontology, KEGG = Kyoto encyclopedia of genes and genomes, LUAD = lung adenocarcinoma, miRNA = micro RNA, PPI = protein-protein interaction.

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Section: Discussionmentioning

confidence: 99%

Reverse predictive analysis of Rhizoma Pinelliae and Rhizoma Coptidis on differential miRNA target genes in lung adenocarcinoma

et al. 2023

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“…Berberine (27) sensitized the BC cells to chemotherapeutic agents via reducing XRCC1mediated base excision repair (Gao et al, 2019). Palmatine (34) reduced the lung metastasis of TNBC via downregulating metastasis-associated protein 1 (MTA1) and increasing p53 level (Ativui et al, 2022). Recently, Li Z. R. et al ( 2020) found that five protoberberine alkaloids (30-34) also showed the inhibitory activities against LSD1.…”

Section: Natural Productsmentioning

confidence: 99%

A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms and therapeutic significance

et al. 2022

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Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most diagnosed cancer worldwide since 2020. Histone methylation is a common biological epigenetic modification mediating varieties of physiological and pathological processes. Lysine-specific demethylase 1 (LSD1), a first identified histone demethylase, mediates the removal of methyl groups from histones H3K4me1/2 and H3K9me1/2 and plays a crucial role in varieties of cancer progression. It is also specifically amplified in breast cancer and contributes to BC tumorigenesis and drug resistance via both demethylase and non-demethylase manners. This review will provide insight into the overview structure of LSD1, summarize its action mechanisms in BC, describe the therapeutic potential of LSD1 inhibitors in BC, and prospect the current opportunities and challenges of targeting LSD1 for BC therapy.

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“…In studies related to its anti-cancer effect, palmatine showed considerable growth inhibition in several human cancer cell lines, such as the HepG2 human liver cancer cell line, CEM T lymphoblast cell line, K III and Lewis lung carcinoma cell lines, and MCF-7 human breast cancer cell line [ 35 , 36 ]. In addition, it exhibited an anti-proliferative effect in human ER + /HER2- breast cancer cell lines, regardless of the tumor type, and suppressed metastasis to the lungs of the 4T1 triple-negative breast cancer cell line [ 37 , 38 ]. Moreover, it induced cell death by inhibiting the PI3K/AKT pathway in human acute myeloid leukemia cell lines [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer effect of palmatine through inhibition of the PI3K/AKT pathway in canine mammary gland tumor CMT-U27 cells

Yoo,

Choi,

Jang

et al. 2023

BMC Vet Res

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Canine mammary gland tumors (CMTs) are the most common and lethal cancers in female dogs. Dysregulated phosphoinositide 3-kinases (PI3K)/AKT pathway reportedly was involved in the growth and metastasis of CMTs. However, there are few studies on therapeutic strategies for targeting the PI3K pathway in CMTs. In this study, we aimed to determine whether palmatine, a natural isoquinoline alkaloid with anti-cancer properties, could inhibit the growth of CMTs and whether the inhibitory effect was mediated through the PI3K/AKT pathway. Our in vitro experiments on CMT-U27, a CMT cell line, showed that palmatine reduced cell proliferation and induced cell death. Western blotting results revealed that palmatine decreased the protein expression of PI3K, PTEN, AKT, and mechanistic target of rapamycin in the PI3K/AKT pathway, which was supported by the results of immunocytochemistry. Additionally, palmatine suppressed the migration and tube formation of canine aortic endothelial cells as well as the migration of CMT U27 cells. Our in vivo results showed that palmatine inhibited tumor growth in a CMT-U27 mouse xenograft model. We observed a decreased expression of proteins in the PI3K/AKT pathway in tumor tissues, similar to the in vitro results. Furthermore, palmatine significantly disrupted the tumor vasculature and inhibited metastasis to adjacent lymph nodes. In conclusion, our findings demonstrate that palmatine exerts anti-cancer effects against CMTs by inhibiting PI3K/AKT signaling pathway, suggesting that palmatine has potential as a canine-specific PI3K inhibitor for the treatment of CMTs.

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Palmatine Attenuates Metastatic Lung Colonization of Triple Negative Breast Cancer Cells

Cited by 7 publications

References 27 publications

Reverse predictive analysis of Rhizoma Pinelliae and Rhizoma Coptidis on differential miRNA target genes in lung adenocarcinoma

Reverse predictive analysis of Rhizoma Pinelliae and Rhizoma Coptidis on differential miRNA target genes in lung adenocarcinoma

A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms and therapeutic significance

Anti-cancer effect of palmatine through inhibition of the PI3K/AKT pathway in canine mammary gland tumor CMT-U27 cells

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